Trial reportPsychopharmacology2016
Nicotine withdrawal alters neural responses to psychosocial stress.
Trial report in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study.Translational psychiatry · 2024Trial
- Brain activation and subjective anxiety during an anticipatory anxiety task is related to clinical outcome during prazosin treatment for alcohol use disorder.NeuroImage. Clinical · 2020Trial
- The neurocomputational signature of decision-making for unfair offers in females under acute psychological stress.Neurobiology of stress · 2024Article
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- Acute and Lifetime Stress and Psychotic Illness: The Roles of Reward and Salience Networks.Journal of psychiatry and brain science · 2022Article
- Time-Varying Functional Connectivity Decreases as a Function of Acute Nicotine Abstinence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Neural mechanisms of acute stress and trait anxiety in adolescents.NeuroImage. Clinical · 2021Article
- Brain Marker Links Stress and Nicotine Abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Neural cue reactivity during acute abstinence predicts short-term smoking relapse.Addiction biology · 2020Article
- Individual differences in emotion dysregulation and trajectory of withdrawal symptoms during a quit attempt among treatment-seeking smokers.Behaviour research and therapy · 2019Article
- Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments.NeuroImage · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionPsychosocial stress is considered to be an important mechanism underlying smoking behavior and relapse. Thus, understanding the effects of acute nicotine withdrawal on responses to stress is important to intervene to prevent stress-induced relapse. The current study investigated the neural correlates of psychosocial stress during acute nicotine withdrawal in chronic smokers.
methodsThirty-nine treatment-seeking smokers were randomized to one of two conditions (abstinent 24 h (n = 21) or smoking as usual (n = 18)). They were then exposed to the Montreal Imaging Stress Task (MIST), a psychosocial stress task consisting of difficult mental arithmetic problems while receiving negative performance feedback while undergoing functional magnetic resonance imaging (fMRI).
resultsSubjective measures of stress increased following the MIST, compared to baseline. Whole brain between-group analysis identified significant activation clusters in four regions for the stress induction minus control contrast: inferior frontal gyrus (IFG), anterior/para cingulate cortex (ACC), precuneus, and supramarginal gyrus (SMG). In all regions, the deprived group showed significantly greater activation compared to the non-deprived group. No significant correlations were found between subjective stress and BOLD signal activation (ps > 0.07).
conclusionsThis study provides new evidence that brain regions previously shown to be predictive of relapse, such as the precuneus and IFG, display heightened neural responses to stress during nicotine deprivation. These data identify the brain regions that may be associated with withdrawal-related stress responses. Increased stress-related activation during nicotine withdrawal may identify those most vulnerable to relapse and represent a target for novel pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.