ArticlePublic health nutrition2016
Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women.
Article in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.Scientific reports · 2021Pooled it
- Effect modification of prenatal folic acid supplementation on the associations of pre-pregnancy BMI and gestational weight gain with offspring birth weight: a large prospective cohort study.European journal of nutrition · 2026Article
- Reference intervals for blood concentrations of folate-related biomarkers in early pregnancy among pregnant women in Qingdao.BMC pregnancy and childbirth · 2026Article
- Red blood cell folate and visceral adipose tissue among young and middle-aged American adults.Frontiers in nutrition · 2025Article
- Association between RBC folate and diabetic nephropathy in Type2 diabetes mellitus patients: a cross-sectional study.Scientific reports · 2024Article
- Maternal Smoking during Pregnancy and its effects on Neural Tube Defects.Iranian journal of child neurology · 2024Article
- Metabolic Interaction Between Folate, Vitamin B12, and Polyunsaturated Fatty Acids in Pregnancy.Advances in experimental medicine and biology · 2023Article
- Associations between folic acid supplement use and folate status biomarkers in the first and third trimesters of pregnancy in the Maternal-Infant Research on Environmental Chemicals (MIREC) Pregnancy Cohort Study.The American journal of clinical nutrition · 2022Article
- Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age.Frontiers in public health · 2022Article
- Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus.Food science & nutrition · 2019Article
- Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor.Archives of medical science : AMS · 2019Article
- Plausible relationship between homocysteine and obesity risk viaDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Association between pre-pregnancy weight status and maternal micronutrient status in early pregnancy.Public health nutrition · 2018Article
- Folate status in women of childbearing age with obesity: a review.Nutrition research reviews · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women.
designA cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual.
settingThe Ottawa Hospital and Kingston General Hospital, Ontario, Canada. SUBJECTS: Pregnant women recruited between 12 and 20 weeks of gestation.
resultsA total of 869 pregnant women recruited from April 2008 to April 2009 were included in the final analysis. Serum folate was inversely associated and RBC folate positively associated with BMI, after adjusting for folic acid supplementation, age, gestational age at blood sample collection, race, maternal education, annual income, smoking and MTHFR 677C→T genotype. In stratified analyses, this differential association was significant in women with the MTHFR CC variant. In women with the CT and TT variants, the differential associations were in the same direction but not significant. Folic acid supplementation during pregnancy did not alter the differential association of BMI with serum and RBC folate concentration. This indicates that the current RBC folate cut-off approach for assessing risk of neural tube defects in obese women may be limited.
conclusionsBMI is inversely associated with serum folate and positively associated with RBC folate in pregnant women, especially for those with the MTHFR CC variant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.