ArticleScientific reports2016
Regulatory mechanisms link phenotypic plasticity to evolvability.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Do alternative reproductive tactics facilitate evolutionary rescue? A comment on Knell & Parrett 2024.Evolution letters · 2026Article
- Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- A neural network model for the evolution of reconstructive social learning.Scientific reports · 2025Article
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
- Thermal Plasticity and Evolutionary Constraints inBiology · 2024Article
- Facilitation of Evolution by Plasticity Scales with Phenotypic Complexity.Animals : an open access journal from MDPI · 2024Article
- Emergence of phenotypic plasticity through epigenetic mechanisms.Evolution letters · 2024Article
- Utilizing developmental dynamics for evolutionary prediction and control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Pleiotropic hubs drive bacterial surface competition through parallel changes in colony composition and expansion.PLoS biology · 2023Article
- Evolution of selfish multicellularity: collective organisation of individual spatio-temporal regulatory strategies.BMC ecology and evolution · 2023Article
- Genetic architecture of dispersal and local adaptation drives accelerating range expansions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Three topological features of regulatory networks control life-essential and specialized subsystems.Scientific reports · 2021Article
- The evolution of social learning as phenotypic cue integration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies.Ecology and evolution · 2021Article
- Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation.PLoS biology · 2021Article
- Phenotypic plasticity explains apparent reverse evolution of fat synthesis in parasitic wasps.Scientific reports · 2021Article
- Transcriptional circuitry atlas of genetic diverse unstimulated murine and human macrophages define disparity in population-wide innate immunity.Scientific reports · 2021Article
- Article
- How to fit in: The learning principles of cell differentiation.PLoS computational biology · 2020Article
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2 authors.
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Abstract
Organisms have a remarkable capacity to respond to environmental change. They can either respond directly, by means of phenotypic plasticity, or they can slowly adapt through evolution. Yet, how phenotypic plasticity links to evolutionary adaptability is largely unknown. Current studies of plasticity tend to adopt a phenomenological reaction norm (RN) approach, which neglects the mechanisms underlying plasticity. Focusing on a concrete question - the optimal timing of bacterial sporulation - we here also consider a mechanistic approach, the evolution of a gene regulatory network (GRN) underlying plasticity. Using individual-based simulations, we compare the RN and GRN approach and find a number of striking differences. Most importantly, the GRN model results in a much higher diversity of responsive strategies than the RN model. We show that each of the evolved strategies is pre-adapted to a unique set of unseen environmental conditions. The regulatory mechanisms that control plasticity therefore critically link phenotypic plasticity to the adaptive potential of biological populations.
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