ArticleAmerican journal of human genetics2016
Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS.
Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Exploring genetic variation that influences brain methylation in attention-deficit/hyperactivity disorder.Translational psychiatry · 2019Pooled it
- Methylation array signals are predictive of chronological age without bisulfite conversion.GeroScience · 2026Article
- Identification of genetic variants influencing methylation in brain with pleiotropic effects on psychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Epigenetic Modulation in Parkinson's Disease and Potential Treatment Therapies.Neurochemical research · 2021Review
- Combined epigenetic/genetic study identified an ALS age of onset modifier.Acta neuropathologica communications · 2021Article
- Analyzing DNA methylation patterns in subjects diagnosed with schizophrenia using machine learning methods.Journal of psychiatric research · 2019Article
- Translational bioinformatics in mental health: open access data sources and computational biomarker discovery.Briefings in bioinformatics · 2019Review
- Prediction of smoking by multiplex bisulfite PCR with long amplicons considering allele-specific effects on DNA methylation.Clinical epigenetics · 2018Article
- A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers.Brain : a journal of neurology · 2018Article
- Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci.Nature communications · 2018Article
- Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies.Molecular psychiatry · 2017Review
- Epigenetic Biomarkers for Parkinson's Disease: From Diagnostics to Therapeutics.Journal of Parkinson's disease · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP microarrays, we performed a comprehensive search of ASM effects in human post-mortem brain and sperm samples (total n = 256) from individuals with major psychosis and control individuals. Depending on the phenotypic category of the brain samples, 1.4%-7.5% of interrogated SNPs exhibited ASM effects. Next, we investigated ASM in the context of genetic studies of schizophrenia and detected that brain ASM SNPs were significantly overrepresented among sub-threshold SNPs from a schizophrenia genome-wide association study (GWAS). Brain ASM SNPs showed a much stronger enrichment in a schizophrenia GWAS than in 17 large GWASs of non-psychiatric diseases and traits, arguing that ASM effects are at least partially tissue specific. Studies of germline and control brain ASM SNPs supported a causal association between ASM and schizophrenia. Finally, significantly higher proportions of ASM SNPs than of non-ASM SNPs were detected at loci exhibiting epigenetic signatures of enhancers and promoters, and they were overrepresented within transcription factor binding regions and DNase I hypersensitive sites. All of these findings collectively indicate that ASM SNPs should be prioritized in follow-up GWASs.
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Registered trials
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