ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Increased Seasonal Variation in Serotonin Transporter Binding in Seasonal Affective Disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Vitamin D Status and Physical Activity during Wintertime in Forensic Inpatients-A Randomized Clinical Trial.Nutrients · 2021Trial
- Seasonal surge for mental health demand in the emergency department of Eradah complex for mental health in the Eastern Province of Saudi Arabia: a retrospective study.The Journal of the Egyptian Public Health Association · 2026Article
- Chronotherapy in the Treatment of Major Depression.Advances in experimental medicine and biology · 2026Review
- A study on electroretinography as a biomarker for seasonal vulnerability in depression.Translational psychiatry · 2025Article
- Identification of photoperiod as a regulator of dopamine-mediated behavior in female mice.Neurobiology of sleep and circadian rhythms · 2025Article
- Establishing Neuron-Specific Enolase Reference Intervals: A Comparative Analysis of Partitioned Approach- and Gender-Based Continuous Age- and Season-Related Models.Diagnostics (Basel, Switzerland) · 2024Article
- Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood.Neurobiology of sleep and circadian rhythms · 2024Article
- Does seasonal variation affect the neuroimmune system? A retrospective [Neuroscience letters · 2024Article
- Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Pharmacological and Non-Pharmacological Treatments for Depression in Parkinson's Disease: An Updated Review.Medicina (Kaunas, Lithuania) · 2023Review
- The Relationship between Character Traits and In Vivo Cerebral Serotonin Transporter Availability in Healthy Subjects: A High-Resolution PET Study with C-11 DASB.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Seasonality of brain function: role in psychiatric disorders.Translational psychiatry · 2023Review
- Light therapy for seasonal affective disorder: correspondence.Annals of medicine and surgery (2012) · 2023Article
- Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies.Frontiers in neuroscience · 2023Review
- Using iterative random forest to find geospatial environmental and Sociodemographic predictors of suicide attempts.Frontiers in psychiatry · 2023Article
- Bright Light Therapy for Parkinson Disease: A Literature Review and Meta-Analysis of Randomized Controlled Trials.Biology · 2021Article
- Validity and Usage of the Seasonal Pattern Assessment Questionnaire (SPAQ) in a French Population of Patients with Depression, Bipolar Disorders and Controls.Journal of clinical medicine · 2021Article
- Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.Neuroscience · 2021Review
- The darkness and the light: diurnal rodent models for seasonal affective disorder.Disease models & mechanisms · 2021Review
- The effects of diet on levels of physical activity during winter in forensic inpatients - A randomized controlled trial.Food & nutrition research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Seasonal affective disorder (SAD) is highly prevalent with rates of 1-6% and greater prevalence at more extreme latitudes; however, there are almost no direct brain investigations of this disorder. In health, serotonin transporter binding potential (5-HTT BPND), an index of 5-HTT levels, is greater throughout the brain in fall-winter compared with spring-summer. We hypothesized that in SAD, this seasonal variation would be greater in brain regions containing structures that regulate affect such as the prefrontal and anterior cingulate cortices (PFC and ACC). Furthermore, given the dimensional nature of SAD symptoms, it was hypothesized that seasonal fluctuation of 5-HTT BPND in the PFC and ACC would be greatest in severe SAD. Twenty SAD and twenty healthy participants underwent [(11)C]DASB positron emission tomography scans in summer and winter to measure seasonal variation in [(11)C]DASB 5-HTT BPND. Seasonal increases in [(11)C]DASB 5-HTT BPND were greater in SAD compared with healthy in the PFC and ACC, primarily due to differences between severe SAD and healthy (severe SAD vs healthy; Mann-Whitney U, U=42.5 and 37.0, p=0.005 and 0.003, respectively; greater magnitude in severe SAD of 35.10 and 14.23%, respectively), with similar findings observed in other regions (U=40.0-62.0, p=0.004-0.048; greater magnitude in severe SAD of 13.16-17.49%). To our knowledge, this is the first brain biomarker identified in SAD. This creates a new opportunity for phase 0 studies to target this phenotype and optimize novel prevention/treatment strategies for SAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.