ArticleSoft matter2016
Sub-cellular modeling of platelet transport in blood flow through microchannels with constriction.
Article in Soft matter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Numerical simulation of red blood cells migration and platelets margination for blood flow in micro-vessels with fusiform aneurysms.Scientific reports · 2025Article
- A wireless, implantable sensor for continuous monitoring of blood leakage after endovascular aneurysm repair.Science advances · 2025Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19.iScience · 2023Article
- The stress-free state of human erythrocytes: Data-driven inference of a transferable RBC model.Biophysical journal · 2023Article
- Cell-scale hemolysis evaluation of intervenient ventricular assist device based on dissipative particle dynamics.Frontiers in physiology · 2023Article
- Multiphysics and multiscale modeling of microthrombosis in COVID-19.PLoS computational biology · 2022Article
- Recent Advances in Computational Modeling of Biomechanics and Biorheology of Red Blood Cells in Diabetes.Biomimetics (Basel, Switzerland) · 2022Article
- Computational investigation of blood cell transport in retinal microaneurysms.PLoS computational biology · 2022Article
- Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.Biophysical reviews · 2021Review
- Integrating blood cell mechanics, platelet adhesive dynamics and coagulation cascade for modelling thrombus formation in normal and diabetic blood.Journal of the Royal Society, Interface · 2021Article
- Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer.Journal of the Royal Society, Interface · 2019Article
- A density-dependent FEM-FCT algorithm with application to modeling platelet aggregation.International journal for numerical methods in biomedical engineering · 2019Article
- Downstream platelet adhesion and activation under highly elevated upstream shear forces.Acta biomaterialia · 2019Article
- Red Blood Cells: Chasing Interactions.Frontiers in physiology · 2019Review
- Quantifying Platelet Margination in Diabetic Blood Flow.Biophysical journal · 2018Article
- Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.Biophysical journal · 2018Article
- The Margination of Particles in Areas of Constricted Blood Flow.Biophysical journal · 2018Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Cellular LevelFrontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Platelet transport through arterial constrictions is one of the controlling processes influencing their adhesive functions and the formation of thrombi. We perform high-fidelity mesoscopic simulations of blood flow in microchannels with constriction, resembling arterial stenoses. The wall shear rates inside the constrictions reach levels as high as ≈8000 s(-1), similar to those encountered in moderate atherosclerotic plaques. Both red blood cells and platelets are resolved at sub-cellular resolution using the Dissipative Particle Dynamics (DPD) method. We perform a systematic study on the red blood cell and platelet transport by considering different levels of constriction, blood hematocrit and flow rates. We find that higher levels of constriction and wall shear rates lead to significantly enhanced margination of platelets, which may explain the experimental observations of enhanced post-stenosis platelet aggregation. We also observe similar margination effects for stiff particles of spherical shapes such as leukocytes. To our knowledge, such numerical simulations of dense blood through complex geometries have not been performed before, and our quantitative findings could shed new light on the associated physiological processes such as ATP release, plasma skimming, and thrombus formation.
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Registered trials
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