Evidence map›Paper›PMID 27087252›Full record

ArticleArtificial organs2016

Extracorporeal Respiratory Support With a Miniature Integrated Pediatric Pump-Lung Device in an Acute Ovine Respiratory Failure Model.

Xufeng Wei, Pablo G Sanchez, Yang Liu, A Claire Watkins, Tieluo Li, Bartley P Griffith, Zhongjun J Wu

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020
    Article
  6. Article
  7. Early in vivo experience with the pediatric continuous-flow total artificial heart.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xufeng WeiDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Pablo G SanchezDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Yang LiuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
A Claire WatkinsDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Tieluo LiDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Bartley P GriffithDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Zhongjun J WuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USUniversity of Louisville · US

Funding

First-in-Human Use of an Artificial Lung for Ambulatory Respiratory SupportR01HL118372 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2013 to 2023
$7.9M
Development of an Artificial Pump-Lung for Respiratory FailureR01HL082631 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P · 2007 to 2011
$3.6M
Linking Multiscale Dynamics of Shear-induced Blood Damage to CFD modelingR01HL088100 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WU, ZHONGJUN JON · 2008 to 2011
$1.7M
NHLBI NIH HHS HHSN268201000014CNHLBI NIH HHS R01 HL082631NHLBI NIH HHS R01 HL088100NHLBI NIH HHS R01 HL118372
6 · The paper itself

Abstract

Respiratory failure is one of the major causes of mortality and morbidity all over the world. Therapeutic options to treat respiratory failure remain limited. The objective of this study was to evaluate the gas transfer performance of a newly developed miniature portable integrated pediatric pump-lung device (PediPL) with small membrane surface for respiratory support in an acute ovine respiratory failure model. The respiratory failure was created in six adult sheep using intravenous anesthesia and reduced mechanical ventilation at 2 breaths/min. The PediPL device was surgically implanted and evaluated for respiratory support in a venovenous configuration between the right atrium and pulmonary artery. The hemodynamics and respiratory status of the animals during support with the device gas transfer performance of the PediPL were studied for 4 h. The animals exhibited respiratory failure 30 min after mechanical ventilation was reduced to 2 breaths/min, indicated by low oxygen partial pressure, low oxygen saturation, and elevated carbon dioxide in arterial blood. The failure was reversed by establishing respiratory support with the PediPL after 30 min. The rates of O

Indexed as

Heart-Lung MachineAcute Lung InjuryAnimalsCarbon DioxideChildDisease Models, AnimalExtracorporeal Membrane OxygenationHeart AtriaHemodynamicsHumansHypercapniaOxygenPulmonary ArteryRespiration, ArtificialRespiratory InsufficiencySheepCarbon DioxideOxygenAnimal modelArtificial lungGas exchangeIntegrated pump-oxygenatorRespiratory failure

Identifiers

PMID27087252
PMCPMC5069079
OpenAlexW2341165894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.