Evidence map›Paper›PMID 27087056›Full record

ArticleScientific reports2016

Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.

Parvathi Haridas, Jacqui A McGovern, Abhishek S Kashyap, D L Sean McElwain, Matthew J Simpson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. AnFrontiers in microbiology · 2020
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Parvathi HaridasInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia.
Jacqui A McGovernInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia.
Abhishek S KashyapInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia.
D L Sean McElwainInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia.
Matthew J SimpsonInstitute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reliable identification of different melanoma cell lines is important for many aspects of melanoma research. Common markers used to identify melanoma cell lines include: S100; HMB-45; and Melan-A. We explore the expression of these three markers in four different melanoma cell lines: WM35; WM793; SK-MEL-28; and MM127. The expression of these markers is examined at both the mRNA and protein level. Our results show that the metastatic cell line, MM127, cannot be detected using any of the commonly used melanoma-associated markers. This implies that it would be very difficult to identify this particular cell line in a heterogeneous sample, and as a result this cell line should be used with care.

Indexed as

Biomarkers, TumorCell Line, TumorCells, Culturedgp100 Melanoma AntigenHumansMART-1 AntigenMelanomaMelanoma-Specific AntigensNeoplasm MetastasisS100 ProteinsSensitivity and SpecificityBiomarkers, Tumorgp100 Melanoma AntigenMART-1 AntigenMelanoma-Specific AntigensPMEL protein, humanS100 Proteins

Identifiers

PMID27087056
PMCPMC4834532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.