ArticleJournal of clinical laboratory analysis2016
Impact of FokI (rs10735810) and BsmI (rs1544410) on Treatment of Chronic HCV Patients With Genotype 4.
Article in Journal of clinical laboratory analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 10 citations in OpenAlex.
- Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population.Journal of immunology research · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimChronic infection with hepatitis C virus (HCV) is a huge problem both globally and at the level of the individual patient. Our aim is to detect the influence of vitamin D receptor gene polymorphisms (BsmI and Fok1) and vitamin D level in HCV patients under treatment with interferon. SUBJECT AND
methodsBlood samples were taken from 103 HCV patients all of them are genotype 4. They were divided into responders (n = 63) and nonresponders (n = 40) according to their response to interferon treatment. Also 120 subjects with matched age and sex were enrolled as controls. All subjects were subjected to history taking, general examination, liver function tests, hepatitis markers, HCV quantitation by real-time polymerase chain reaction (PCR), DNA extraction from whole blood, PCR-restriction fragment length polymorphism (RFLP) for genotyping, and quantitation of vitamin D level by ELISA.
resultsThere were significant differences between responders and nonresponders in the mean values of vitamin D (P = 0.001) as well as the prevalence of single nucleotide polymorphism (SNP) BsmI (Bb) (P = 0.02). Meanwhile, no significant differences in Fok1 genotype between responders and nonresponders to interferon therapy of HCV patients in all genotypes [FF, Ff, ff) (P = 0.34, 0.091, and 0.43), respectively.
conclusionBsmI and vitamin D level in chronic liver disease patients are predictors of response to combination therapy of HCV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.