Evidence map›Paper›PMID 27086974›Full record

ArticleBrain research2016

Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.

Stacey L Kigar, Liza Chang, Margaret R Hayne, Nicolette T Karls, Anthony P Auger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Preventing epigenetic traces of caregiver maltreatment: A role for HDAC inhibition.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019
    Article
  4. Review
  5. Article
  6. Epigenetic Landscapes of the Adversity-Exposed Brain.Progress in molecular biology and translational science · 2018
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stacey L KigarMolecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States. Electronic address: kigar@wisc.edu.
Liza ChangDepartment of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States. Electronic address: lchang9@wisc.edu.
Margaret R HayneDepartment of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States.
Nicolette T KarlsDepartment of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States.
Anthony P AugerDepartment of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States; Neuroscience Training Program, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, United States. Electronic address: apauger@wisc.edu.
University of Wisconsin–Madison · US

Funding

Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Precise spatiotemporal epigenetic regulation of the genome facilitates species-typical development; sexual differentiation of the brain by gonadal hormones and sex chromosomes causes extensive epigenetic reprogramming of many cells in the body, including the brain, and may indirectly predispose males and females to different psychiatric conditions. We and others have demonstrated sex differences in DNA methylation, as well as in the enzymes that form, or 'write', this epigenetic modification. However, while a growing body of evidence suggests that DNA methylation undergoes rapid turnover and is dynamically regulated in vivo, to our knowledge no studies have been done investigating whether sex differences exist in the epigenetic 'erasers' during postnatal development. Here we report sex differences in the expression of growth arrest and DNA damage inducible factor β (Gadd45b), but not family members α (a) or γ (g), in the neonatal and juvenile rodent amygdala.

Indexed as

Sex CharacteristicsAmygdalaAnimalsAnimals, NewbornAntigens, DifferentiationCell Cycle ProteinsDihydrotestosteroneDNA MethylationEstrogensFemaleGADD45 ProteinsHormonesHypothalamusIntracellular Signaling Peptides and ProteinsMaleModels, AnimalAntigens, DifferentiationCell Cycle ProteinsDihydrotestosteroneEstrogensGadd45a protein, ratGadd45b protein, ratGADD45 ProteinsHormonesIntracellular Signaling Peptides and ProteinsNuclear ProteinsRNA, MessengerTestosteroneAmygdalaEpigeneticsGadd45bSex differences

Identifiers

PMID27086974
PMCPMC6701186
OpenAlexW2341647502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.