Evidence map›Paper›PMID 27086928›Full record

ArticleOncogene2016

Intestinal knockout of Nedd4 enhances growth of Apc

C Lu, C Thoeni, A Connor, H Kawabe, S Gallinger, D Rotin

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  7. Review
  8. Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.International journal of molecular sciences · 2022
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

C LuCell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Toronto, Ontario, Canada.
C ThoeniCell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Toronto, Ontario, Canada.
A ConnorMount Sinai Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
H KawabeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Goettingen, Germany.
S GallingerMount Sinai Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
D RotinCell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Toronto, Ontario, Canada.
Hospital for Sick Children · CAMax Planck Institute of Experimental Medicine · DESickKids Foundation · CAUniversity Health Network · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nedd4 (Nedd4-1) is an E3 ubiquitin ligase that belongs to the HECT family and comprises a C2-WW(n)-HECT domain architecture. Although it has been reported to regulate growth factor receptors and cellular signaling, its role in cancer development has been controversial, with some studies proposing that it promotes cancer while others suggest it inhibits tumor growth. Here, we tested the effect of Nedd4 on intestinal tumor formation and growth using Nedd4-knockout mice (Nedd4 floxed (fl) mice crossed to villin-Cre mice). Although we find that knockout of Nedd4 on its own does not cause tumor growth, its knockout in the context of Apc

Indexed as

Genes, APCAnimalsBiomarkersCell Transformation, NeoplasticColonic NeoplasmsDisease Models, AnimalEndosomal Sorting Complexes Required for TransportGene ExpressionGene Knockout TechniquesGenes, ReporterHomozygoteImmunohistochemistryIntestinal MucosaIntestinesMiceMice, KnockoutBiomarkersEndosomal Sorting Complexes Required for TransportNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesUbiquitin-Protein Ligases

Identifiers

PMID27086928
OpenAlexW2339282390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.