Evidence map›Paper›PMID 27086882›Full record

ReviewBest practice & research. Clinical gastroenterology2016

Physiology of Intestinal Absorption and Secretion.

Pawel R Kiela, Fayez K Ghishan

Open access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 334 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 1 pooled it
26.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 1 synthesis or guideline pooled it, 680 citations in OpenAlex.

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274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pawel R KielaDepartment of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ 85724, USA; Department of Immunobiology, University of Arizona Health Sciences Center, 1656 E. Mabel St., Tucson, AZ 85724, USA. Electronic address: pkiela@peds.arizona.edu.
Fayez K GhishanDepartment of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ 85724, USA. Electronic address: fghishan@peds.arizona.edu.
University of Arizona · US

Funding

DEVELOPMENT OF INTESTINAL ION TRANSPORTR01DK041274 · NIDDK · VANDERBILT UNIVERSITY · PI GHISHAN, FAYEZ KHALAF, KIELA, PAWEL R · 1988 to 2016
$5.5M
DEVELOPMENT OF INTESTINAL TRANSPORT OF CA++ AND PIR37DK033209 · NIDDK · UNIVERSITY OF ARIZONA · PI GHISHAN, FAYEZ KHALAF · 1995 to 2017
$4.7M
NIDDK NIH HHS R01 DK041274NIDDK NIH HHS R37 DK033209
6 · The paper itself

Abstract

Virtually all nutrients from the diet are absorbed into blood across the highly polarized epithelial cell layer forming the small and large intestinal mucosa. Anatomical, histological, and functional specializations along the gastrointestinal tract are responsible for the effective and regulated nutrient transport via both passive and active mechanisms. In this chapter, we summarize the current state of knowledge regarding the mechanism of intestinal absorption of key nutrients such as sodium, anions (chloride, sulfate, oxalate), carbohydrates, amino acids and peptides, lipids, lipid- and water-soluble vitamins, as well as the major minerals and micronutrients. This outline, including the molecular identity, specificity, and coordinated activities of key transport proteins and genes involved, serves as the background for the following chapters focused on the pathophysiology of acquired and congenital intestinal malabsorption, as well as clinical tools to test and treat malabsorptive symptoms.

Indexed as

HumansIntestinal AbsorptionIntestinal MucosaIntestinal SecretionsAmino acidsCarbohydratesChlorideEpithelial transportLipidsMicronutrientsMineralsOxalateShort chain fatty acidsSodiumSulfatevitamins

Identifiers

PMID27086882
PMCPMC4956471
OpenAlexW2257201151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.