ArticleJournal of periodontology2016
Vitamin D Status and Tooth Loss in Postmenopausal Females: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study.
Article in Journal of periodontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Vitamin D deficiency and oral health: a systematic review of literature.BMC oral health · 2025Pooled it
- The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Evaluation of Vitamin D and of Some Biomarkers of Bone Remodelling (CTX-1, Osteocalcin, BALP) in Subjects with Periapical Inflammatory Cysts: An Observational Study.Journal of clinical medicine · 2025Article
- The Role of Serum Vitamin D Levels and Vitamin D Receptor (Children (Basel, Switzerland) · 2024Article
- Alcohol Consumption and the Diversity of the Oral Microbiome in Postmenopausal Women.The Journal of nutrition · 2024Article
- Association between periodontal disease and osteoporosis in postmenopausal women: A systematic review and meta-analysis.Heliyon · 2023Review
- Osteoporosis and periodontal diseases - An update on their association and mechanistic links.Periodontology 2000 · 2022Review
- Evaluation of the association between osteoporosis and periodontitis in postmenopausal women: A clinical and radiographic study.Dental research journal · 2022Article
- Low serum 25-hydroxyvitamin D levels, tooth loss, and the prevalence of severe periodontitis in Koreans aged 50 years and older.Journal of periodontal & implant science · 2020Article
- Association of Vitamin D With Periodontal Disease: A Narrative Review.Oral health & preventive dentistry · 2020Review
- Could Vitamin D influence risk for Periodontal Disease - to "D" or not to "D"?Current oral health reports · 2020Article
- The Buffalo OsteoPerio Studies: Summary of our findings and the unique contributions of Robert J. Genco, DDS, PhD.Current oral health reports · 2020Article
- Icariin prevents oestrogen deficiency-induced alveolar bone loss through promoting osteogenesis via STAT3.Cell proliferation · 2020Article
- Epidemiologic evaluation of Nhanes for environmental Factors and periodontal disease.Scientific reports · 2019Article
- Article
- Osteoporosis and Periodontitis.Current osteoporosis reports · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVitamin D is hypothesized to reduce risk for tooth loss via its influence on bone health, inflammation, and the immune response. The association between plasma 25-hydroxyvitamin D [25(OH)D] concentrations and prevalence and 5-year incidence of tooth loss in a cohort of postmenopausal females was examined.
methodsParticipants underwent oral examinations at study baseline (1997 to 2000) and follow-up (2002 to 2005) to determine the number of missing teeth and 5-year incidence of tooth loss, respectively. At both visits, females self-reported reasons for each missing tooth. At baseline, 152 females reported no history of tooth loss, and 628 were categorized as reporting a history of tooth loss as a result of periodontal disease (n = 70) or caries (n = 558) (total n = 780). At follow-up, 96, 376, 48, and 328 females were categorized into the aforementioned categories related to tooth loss (total n = 472). Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for tooth loss by category of baseline 25(OH)D (nmol/L) concentrations. Models were adjusted for age, income, smoking status, frequency of dental visits, waist circumference, and recreational physical activity. P value for trend was estimated using continuous concentrations of 25(OH)D.
resultsAmong females with 25(OH)D ≥50 (adequate vitamin D status) compared to <50 nmol/L (deficient/inadequate), the adjusted ORs were 1.24 (95% CI = 0.82 to 1.87), P-trend = <0.05 for the history (prevalence) of tooth loss resulting from periodontal disease or caries and 1.07 (95% CI = 0.62 to 1.85), P-trend = 0.11 for the incidence of tooth loss resulting from periodontal disease or caries. No statistically significant association was observed between 25(OH)D and the history or incidence of tooth loss caused by periodontal disease. An increased odds of the history of tooth loss attributable to caries was observed with increasing concentrations of 25(OH)D (P-trend = <0.05) but was not confirmed in prospective analyses.
conclusionIn this cohort of postmenopausal females, the data do not support an association between vitamin D status and tooth loss.
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