Evidence map›Paper›PMID 27086309›Full record

SynthesisLangenbeck's archives of surgery2016

Use of PET tracers for parathyroid localization: a systematic review and meta-analysis.

Wouter P Kluijfhout, Jesse D Pasternak, Frederick Thurston Drake, Toni Beninato, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Isabel E Allen, Menno R Vriens, Bart de Keizer and 2 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Langenbeck's archives of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Comparative performance ofEuropean journal of nuclear medicine and molecular imaging · 2026
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  9. Article
  10. Endocrinology application of molecular imaging: current role of PET/CT.Journal of endocrinological investigation · 2024
    Review
  11. Cost-effectiveness of one-stop-shop [European journal of nuclear medicine and molecular imaging · 2024
    Article
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Wouter P KluijfhoutDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA. wpkluijfhout@gmail.com.
Jesse D PasternakDepartment of Surgery, University Health Network, Toronto, ON, Canada.
Frederick Thurston DrakeDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Toni BeninatoDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Jessica E GosnellDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Wen T ShenDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Quan-Yang DuhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Isabel E AllenDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Menno R VriensDepartment of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Bart de KeizerDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
Miguel H PampaloniDepartment of Nuclear Medicine, University of California San Francisco, San Francisco, CA, USA.
Insoo SuhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity Medical Center Utrecht · NLUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe great spatial and temporal resolution of positron emission tomography might provide the answer for patients with primary hyperparathyroidism (pHPT) and non-localized parathyroid glands. We performed a systematic review of the evidence regarding all investigated tracers.

methodsA study was considered eligible when the following criteria were met: (1) adults ≥17 years old with non-familial pHPT, (2) evaluation of at least one PET isotope, and (3) post-surgical and pathological diagnosis as the gold standard. Performance was expressed in sensitivity and PPV.

resultsTwenty-four papers were included subdivided by radiopharmaceutical: 14 studies investigated L-[

conclusionsThe results of our meta-analysis show that 11C-MET PET has an overall good sensitivity and PPV and may be considered a reliable second-line imaging modality to enable minimally invasive parathyroidectomy. Our literature review suggests that 18F-FCH PET may produce even greater accuracy and should be further investigated using both low-dose CT and MRI for anatomical correlation.

Indexed as

Positron-Emission TomographyRadiopharmaceuticalsCarbon RadioisotopesHumansHyperparathyroidism, PrimaryMethionineParathyroidectomyCarbon RadioisotopesMethionineRadiopharmaceuticals11C-Methionine18F-FluorocholineMinimal invasive parathyroidectomyPET/CTPrimary hyperparathyroidism

Identifiers

PMID27086309
PMCPMC5086346
OpenAlexW2337805229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.