ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
Myelomeningocele - a single institute analysis of the years 2007 to 2015.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Orthopedic management of myelomeningocele with a multidisciplinary approach: a systematic review of the literature.Journal of orthopaedic surgery and research · 2021Pooled it
- Myelomeningocele Surgery over the 10 Years Following the MOMS Trial: A Systematic Review of Outcomes in Prenatal versus Postnatal Surgical Repair.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Outcomes of Postnatal Myelomeningocele Repair in a Japanese Single-center Cohort: A Comparison with the Management of Myelomeningocele Study Trial.Neurologia medico-chirurgica · 2026Article
- Clinical Outcomes of Myelomeningocele Defect Closure: 10-year Experience from a Single Center.Journal of plastic and reconstructive surgery · 2026Article
- Incidence of neural tube defects in tertiary care university hospital in Bangladesh.Clinical and experimental pediatrics · 2025Article
- Differences in brain development and need for CSF diversion based on MMC level: Comparison between prenatal and postnatal repair.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Impact of surgical timing and concomitant anomalies on neonatal meningomyelocele outcomes: a single-center experience.Neurosurgical review · 2025Article
- Concurrent myelomeningocele and sagittal craniosynostosis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Fetal MRI prior to intrauterine surgery of open neural tube defects: What does the radiologist need to know.La Radiologia medica · 2023Review
- Myelomeningocele as an anomaly of secondary neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Postnatal Repair of Open Neural Tube Defects: A Single Center with 90-Month Interdisciplinary Follow-Up.Journal of clinical medicine · 2021Article
- Retrospective analysis of early- and late-operated meningomyelocele patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Shunt timing in meningomyelocele and clinical results: analysis of 80 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Shunt revision rates in myelomeningocele patients in the first year of life: a retrospective study of 52 patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- How much do plastic surgeons add to the closure of myelomeningoceles?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- The problem with myelomeningoceles, hydrocephalus, and progressive neurological deficits-what do we know?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Fetal Pathology of Neural Tube Defects - An Overview of 68 Cases.Geburtshilfe und Frauenheilkunde · 2017Article
- A comparison of the MOMS trial results to a contemporaneous, single-institution, postnatal closure cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter the introduction of folate supplementation, the number of open spinal dysraphism was successfully reduced over time. In 2007, the department for pediatric neurosurgery was established in the children's hospital. Since then, newborns with myelomeningocele (MMC), the most common form of open neural tube defects (NTD), are treated here. The aim of this study is to present the concepts applied to and experiences resulting from treatment of MMC.
methodsRecords of all newborns with MMC treated surgically during the period January 2007 to August 2015 in our institution were analyzed. Children, who were previously operated in utero were excluded. The type of neural tube defect, its location, associated comorbidities, and ambulation were recorded.
resultsForty-eight children (25 males, 23 females) with spinal dysraphism were included in the analysis. In nearly 90 % of the cases, the repair of the MMC was done on the day of delivery. The follow-up period ranges from 9 weeks to 8 9/12 years (loss of follow-up in 2 cases). In 19 %, the defect remained undetected during gestation and in one case, carbamazepine was taken despite pregnancy. In 36 children (75 %), we found a Chiari malformation type II (CMII) associated with myelomeningocele. 85.4 % suffered from hydrocephalus and implantation of a shunt was necessary. In cases of bladder impairment, an intermittent catheterization was the most common management (83.3 %); no bladder augmentation was required. Twelve children required orthopedic surgery. Twenty-three of 33 patients (70 %) are ambulatory w/wo orthoses and devices. The 13 children who are younger than 2 years were considered separately to assess the motor activity safely.
conclusionsOur data show that neural tube defects to this day can remain undetected despite medical care during pregnancy. The most common associated diseases with MMC are Chiari II malformations and hydrocephalus. In the seven cases of simultaneous repair of MMC with shunt implantation, no additional complications were encountered. An interdisciplinary approach was allowed in a high percentage independence and social continence.
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