Evidence map›Paper›PMID 27085996›Full record

Trial reportEuropean journal of applied physiology2016

Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial.

Yosuke Tsuchiya, Kenichi Yanagimoto, Koichi Nakazato, Kohsuke Hayamizu, Eisuke Ochi

Erratum issued Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07237113 (Effects of Omega-3 Fatty Acid Supplementation on Muscle Damage and Oxylipin Production Induced by Eccentric Exercise in Young Men), which is not on this map. Cited by 46 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 4 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07237113 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Omega-3 Fatty Acid Supplementation on Muscle Damage and Oxylipin Production Induced by Eccentric Exercise in Young Men

TypeinterventionalSponsorInstituto de Ciencias de la Salud, Universidad de O'HigginsRan2021 to 2024Enrolled30ConditionsDamage MuscleArmsPlacebo, Omega
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Effects of LCNutrients · 2026
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  14. Re-esterified DHA improves ventilatory threshold 2 in competitive amateur cyclists.Journal of the International Society of Sports Nutrition · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Yosuke TsuchiyaLaboratory of Health and Sports Sciences, Meiji Gakuin University, Kanagawa, Japan.
Kenichi YanagimotoHuman Life Science R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.
Koichi NakazatoGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Kohsuke HayamizuGeneral Health Medical Center, Yokohama University of Pharmacy, Kanagawa, Japan.
Eisuke OchiFaculty of Bioscience and Applied Chemistry, Hosei University, Tokyo, Japan. ochi@hosei.ac.jp.
Hosei University · JPMeiji Gakuin University · JPNippon Sport Science University · JPNippon Suisan Kaisha (Japan) · JPYokohama University of Pharmacy · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the effect of eicosapentaenoic and docosahexaenoic acids-rich fish oil (EPA + DHA) supplementation on eccentric contraction-induced muscle damage.

methodsTwenty-four healthy men were randomly assigned to consume the EPA + DHA supplement (EPA, n = 12) or placebo (PL, n = 12) by the double-blind method. Participants consumed EPA + DHA or placebo supplement for 8 weeks prior to exercise and continued it until 5 days after exercise. The EPA group consumed EPA + DHA-rich fish oil containing 600 mg EPA and 260 mg DHA per day. Subjects performed five sets of six maximal eccentric elbow flexion exercises. Changes in the maximal voluntary contraction (MVC) torque, range of motion (ROM), upper arm circumference, muscle soreness as well as serum creatine kinase, myoglobin, IL-6, and TNF-α levels in blood were assessed before, immediately after, and 1, 2, 3, and 5 days after exercise.

resultsMVC was significantly higher in the EPA group than in the PL group at 2-5 days after exercise (p < 0.05). ROM was also significantly greater in the EPA group than in the PL group at 1-5 days after exercise (p < 0.05). At only 3 days after exercise, muscle soreness of the brachialis was significantly greater in the PL group than in the EPA group (p < 0.05), with a concomitant increase in serum IL-6 levels in the PL group.

conclusionEight-week EPA + DHA supplementation attenuates strength loss and limited ROM after exercise. The supplementation also attenuates muscle soreness and elevates cytokine level, but the effect is limited.

Indexed as

AdultDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodDrug CombinationsEicosapentaenoic AcidFatty Acids, Omega-3Fish OilsHumansMaleMuscle StrengthMuscle WeaknessMyalgiaPlacebo EffectRange of Motion, ArticularResistance TrainingDocosahexaenoic AcidsDrug CombinationsEicosapentaenoic AcidFatty Acids, Omega-3Fish OilsDocosahexaenoic acidsEicosapentaenoic acidLengthening contractionsMuscle dysfunctionMuscle strengthSupplement

Identifiers

PMID27085996
PMCPMC4875060
OpenAlexW2341271312

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.