Evidence map›Paper›PMID 27085880›Full record

ArticleBehavior genetics2016

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.

Helen M Kamens, Robin P Corley, Phillip A Richmond, Todd M Darlington, Robin Dowell, Christian J Hopfer, Michael C Stallings, John K Hewitt, Sandra A Brown, Marissa A Ehringer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Helen M KamensDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO, 80309, USA.
Phillip A RichmondBioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Todd M DarlingtonInstitute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO, 80309, USA.
Robin DowellBioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Christian J HopferDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO, 80309, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO, 80309, USA.
Sandra A BrownDepartment of Psychology and Psychiatry, University of California San Diego, San Diego, CA, USA.
Marissa A EhringerInstitute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO, 80309, USA. marissa.ehringer@colorado.edu.
University of Colorado Boulder · USPennsylvania State University · USUniversity of California, San Diego · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
Pilot, Mentoring, and Professional Development CoreP50DA039838 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LI, RUNZE · 2015 to 2019
$13.9M
GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCER01DA012845 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 2000 to 2012
$7.1M
Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Genetics and Progression of Early-onset Substance Dependence and HIV RiskR01DA035804 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J, STALLINGS, MICHAEL CRAIG · 2014 to 2018
$4.9M
Translational studies of nicotinic receptor genes: alcohol and nicotine behaviorsR01AA017889 · NIAAA · UNIVERSITY OF COLORADO · PI EHRINGER, MARISSA A · 2009 to 2013
$2.6M
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders ResearchK24DA032555 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J · 2013 to 2022
$1.9M
Genetics of Adolescent Antisocial Drug DependenceR01DA021905 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WALL, TAMARA L · 2008 to 2012
$1.9M
Genetics of Alcohol and Nicotine BehaviorsK01AA019447 · NIAAA · UNIVERSITY OF COLORADO · PI KAMENS, HELEN M · 2011 to 2015
$695k
NIAAA NIH HHS K01 AA019447NIAAA NIH HHS R01 AA017889NIDA NIH HHS K24 DA032555NIDA NIH HHS P50 DA039838NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA035804NIDA NIH HHS T32 DA017637
6 · The paper itself

Abstract

Common SNPs in nicotinic acetylcholine receptor genes (CHRN genes) have been associated with drug behaviors and personality traits, but the influence of rare genetic variants is not well characterized. The goal of this project was to identify novel rare variants in CHRN genes in the Center for Antisocial Drug Dependence (CADD) and Genetics of Antisocial Drug Dependence (GADD) samples and to determine if low frequency variants are associated with antisocial drug dependence. Two samples of 114 and 200 individuals were selected using a case/control design including the tails of the phenotypic distribution of antisocial drug dependence. The capture, sequencing, and analysis of all variants in 16 CHRN genes (CHRNA1-7, 9, 10, CHRNB1-4, CHRND, CHRNG, CHRNE) were performed independently for each subject in each sample. Sequencing reads were aligned to the human reference sequence using BWA prior to variant calling with the Genome Analysis ToolKit (GATK). Low frequency variants (minor allele frequency < 0.05) were analyzed using SKAT-O and C-alpha to examine the distribution of rare variants among cases and controls. In our larger sample, the region containing the CHRNA6/CHRNB3 gene cluster was significantly associated with disease status using both SKAT-O and C-alpha (unadjusted p values <0.05). More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls. These data support a role for genetic variants in CHRN genes and antisocial drug behaviors.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAdolescentAntisocial Personality DisorderFemaleGene FrequencyHumansMaleQuality ControlReceptors, NicotinicSoftwareYoung AdultCHRNA6 protein, humanCHRNB3 protein, humanReceptors, NicotinicAntisocial drug dependenceAssociationLow frequency variantsNicotinic acetylcholine receptorSequence

Identifiers

PMID27085880
PMCPMC4975622
OpenAlexW2338826478

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.