Evidence map›Paper›PMID 27085522›Full record

ArticlePediatric radiology2016

Diffusion tensor imaging in children with tuberous sclerosis complex: tract-based spatial statistics assessment of brain microstructural changes.

Anastasia K Zikou, Vasileios G Xydis, Loukas G Astrakas, Iliada Nakou, Loukia C Tzarouchi, Meropi Tzoufi, Maria I Argyropoulou

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Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Anastasia K ZikouDepartment of Radiology, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Vasileios G XydisDepartment of Radiology, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Loukas G AstrakasDepartment of Medical Physics, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Iliada NakouDepartment of Child Health, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Loukia C TzarouchiDepartment of Radiology, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Meropi TzoufiDepartment of Child Health, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Maria I ArgyropoulouDepartment of Radiology, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece. margyrop@cc.uoi.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is evidence of microstructural changes in normal-appearing white matter of patients with tuberous sclerosis complex.

objectiveTo evaluate major white matter tracts in children with tuberous sclerosis complex using tract-based spatial statistics diffusion tensor imaging (DTI) analysis. MATERIALS AND

methodsEight children (mean age ± standard deviation: 8.5 ± 5.5 years) with an established diagnosis of tuberous sclerosis complex and 8 age-matched controls were studied. The imaging protocol consisted of T1-weighted high-resolution 3-D spoiled gradient-echo sequence and a spin-echo, echo-planar diffusion-weighted sequence. Differences in the diffusion indices were evaluated using tract-based spatial statistics.

resultsTract-based spatial statistics showed increased axial diffusivity in the children with tuberous sclerosis complex in the superior and anterior corona radiata, the superior longitudinal fascicle, the inferior fronto-occipital fascicle, the uncinate fascicle and the anterior thalamic radiation. No significant differences were observed in fractional anisotropy, mean diffusivity and radial diffusivity between patients and control subjects. No difference was found in the diffusion indices between the baseline and follow-up examination in the patient group.

conclusionPatients with tuberous sclerosis complex have increased axial diffusivity in major white matter tracts, probably related to reduced axonal integrity.

Indexed as

Diffusion Magnetic Resonance ImagingDiffusion Tensor ImagingChildChild, PreschoolFemaleHumansMaleRetrospective StudiesTuberous SclerosisWhite MatterCentral nervous systemChildDiffusion tensor imagingMagnetic resonance imagingTract-based spatial statisticsTuberous sclerosis complex

Identifiers

PMID27085522

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