Evidence map›Paper›PMID 27084943›Full record

ArticleNucleic acids research2016

MAGIC-web: a platform for untargeted and targeted N-linked glycoprotein identification.

T Mamie Lih, Wai-Kok Choong, Chen-Chun Chen, Cheng-Wei Cheng, Hsin-Nan Lin, Ching-Tai Chen, Hui-Yin Chang, Wen-Lian Hsu, Ting-Yi Sung

Abstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Bioinformatics in Immunoglobulin Glycosylation Analysis.Experientia supplementum (2012) · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T Mamie LihBioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan Institute of Information Science, Academia Sinica, Taipei 11529, Taiwan Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan.
Wai-Kok ChoongInstitute of Information Science, Academia Sinica, Taipei 11529, Taiwan.
Chen-Chun ChenGenomics Research Center, Academia Sinica, Taipei 11529, Taiwan Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Cheng-Wei ChengBioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan Institute of Information Science, Academia Sinica, Taipei 11529, Taiwan Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan.
Hsin-Nan LinInstitute of Information Science, Academia Sinica, Taipei 11529, Taiwan.
Ching-Tai ChenInstitute of Information Science, Academia Sinica, Taipei 11529, Taiwan.
Hui-Yin ChangBioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan Institute of Information Science, Academia Sinica, Taipei 11529, Taiwan Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan.
Wen-Lian HsuInstitute of Information Science, Academia Sinica, Taipei 11529, Taiwan.
Ting-Yi SungInstitute of Information Science, Academia Sinica, Taipei 11529, Taiwan tsung@iis.sinica.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAGIC-web is the first web server, to the best of our knowledge, that performs both untargeted and targeted analyses of mass spectrometry-based glycoproteomics data for site-specific N-linked glycoprotein identification. The first two modules, MAGIC and MAGIC+, are designed for untargeted and targeted analysis, respectively. MAGIC is implemented with our previously proposed novel Y1-ion pattern matching method, which adequately detects Y1- and Y0-ion without prior information of proteins and glycans, and then generates in silico MS(2) spectra that serve as input to a database search engine (e.g. Mascot) to search against a large-scale protein sequence database. On top of that, the newly implemented MAGIC+ allows users to determine glycopeptide sequences using their own protein sequence file. The third module, Reports Integrator, provides the service of combining protein identification results from Mascot and glycan-related information from MAGIC-web to generate a complete site-specific protein-glycan summary report. The last module, Glycan Search, is designed for the users who are interested in finding possible glycan structures with specific numbers and types of monosaccharides. The results from MAGIC, MAGIC+ and Reports Integrator can be downloaded via provided links whereas the annotated spectra and glycan structures can be visualized in the browser. MAGIC-web is accessible from http://ms.iis.sinica.edu.tw/MAGIC-web/index.html.

Indexed as

InternetSoftwareComputer SimulationDatabases, ProteinGlycopeptidesGlycoproteinsHumansMass SpectrometryPolysaccharidesProteomicsSearch EngineUser-Computer InterfaceWeb BrowserGlycopeptidesGlycoproteinsPolysaccharides

Identifiers

PMID27084943
PMCPMC4987873

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.