ArticleBMC psychiatry2016
Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study.
Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.Neuromodulation : journal of the International Neuromodulation Society · 2019Trial
- Sertraline Effects on Striatal Resting-State Functional Connectivity in Youth With Obsessive-Compulsive Disorder: A Pilot Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.Translational psychiatry · 2017Trial
- Sex-specific alterations of intrinsic brain activity and functional connectivity in adolescent obsessive-compulsive disorder.Medical & biological engineering & computing · 2026Article
- Altered anterior cingulate cortex functional connectivity in treatment-naïve obsessive-compulsive disorder: a resting-state fMRI study.Frontiers in psychiatry · 2026Article
- Immunomodulatory treatment may change functional and structural brain imaging in severe mental disorders.Brain, behavior, & immunity - health · 2024Article
- The Seeking Proxies for Internal States (SPIS) Model of OCD - A Comprehensive Review of Current Findings and Implications for Future Directions.Current neuropharmacology · 2024Review
- Pathological Networking of Gray Matter Dendritic Density With Classic Brain Morphometries in OCD.JAMA network open · 2023Article
- Different degrees of nodes behind obsessive-compulsive symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
- Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder.BMC psychiatry · 2022Article
- Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive-Compulsive Disorder.Brain sciences · 2022Article
- A study on diffusion tensor imaging in patients with untreated first-episode obsessive-compulsive disorder.Quantitative imaging in medicine and surgery · 2022Article
- Temporal variability of regional intrinsic neural activity in drug-naïve patients with obsessive-compulsive disorder.Human brain mapping · 2021Article
- Comparing Effectiveness Between a Mobile App Program and Traditional Cognitive Behavior Therapy in Obsessive-Compulsive Disorder: Evaluation Study.JMIR mental health · 2021Article
- Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Frontoparietal and salience network alterations in obsessive–compulsive disorder: insights from independent component and sliding time window analysesJournal of psychiatry & neuroscience : JPN · 2020Article
- Investigating the predictive value of different resting-state functional MRI parameters in obsessive-compulsive disorder.Translational psychiatry · 2019Article
- Altered Functional Connectivity Between the Cerebellum and the Cortico-Striato-Thalamo-Cortical Circuit in Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2019Article
- Neuroimaging findings in obsessive-compulsive disorder: A narrative review to elucidate neurobiological underpinnings.Indian journal of psychiatry · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious neuroimaging data indicated that the dysfunction in cortico-striato-thalamo-cortical (CSTC) circuit contributed to the neuropathological mechanism of obsessive-compulsive disorder (OCD). Whereas, emerging work has shown that the pathophysiology of OCD might be related to more widely distributed large-scale brain systems including limbic system and the salience network. This study aims to investigate the aberrant spontaneous neuronal activity within the whole brain, and its association with the symptom severity for unmedicated OCD patients.
methodTwenty-eight unmedicated OCD adults and twenty-eight matched healthy controls were recruited for a resting state functional magnetic resonance imaging (fMRI) study. The amplitude of low-frequency fluctuation (ALFF) analysis over whole brain was performed to examine the intrinsic cerebral activity of subjects. In addition, we conducted the voxel-based Pearson's correlative analysis to probe into the relationship between ALFF values and symptom severity for OCD patients.
resultsOur results showed that OCD patients had increased ALFF measures in the left frontopolar cortex and left orbital frontal cortex (OFC), with decreased ALFF values in the right insula. Moreover, the right insular intrinsic activity was significantly correlated with total YBOCS score (r = 0.611, p = 0.002) and compulsion score (r = 0.640, p = 0.001) for OCD patients.
conclusionThe results showed abnormal intrinsic neuronal activity within CSTC circuit and salience network of OCD patients. Our finding of aberrant insular activity advanced the understanding of OCD pathophysiology beyond the traditional CSTC circuit. To the best of our knowledge, it is the first finding about a reduced insular activity at the resting state for unmedicated OCD patients, which might serve as an informative biomarker for OCD pathophysiology.
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