ReviewInternational journal of radiation oncology, biology, physics2016
Improving Outcomes for Esophageal Cancer using Proton Beam Therapy.
Review in International journal of radiation oncology, biology, physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03619317 (Identification of Chemo and Radiation Induced Systolic and Diastolic Myocardial Dysfunction in Patients With Cancer in Oesophagus and Gastroesophagael Junction - a Prospective Study), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Chemo and Radiation Induced Systolic and Diastolic Myocardial Dysfunction in Patients With Cancer in Oesophagus and Gastroesophagael Junction - a Prospective Study
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Concurrent chemoradiotherapy using proton beams can reduce cardiopulmonary morbidity in esophageal cancer patients: a systematic review.Esophagus : official journal of the Japan Esophageal Society · 2023Pooled it
- Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Trial
- Advances in radiotherapy in the treatment of esophageal cancer.World journal of clinical oncology · 2025Article
- Feasibility study for proton dose calculation of esophageal squamous cell carcinoma based on stopping power ratio directly derived from dual energy CT.Frontiers in oncology · 2025Article
- Autodelineation methods in a simulated fully automated proton therapy workflow for esophageal cancer.Physics and imaging in radiation oncology · 2024Article
- Risk stratification of postoperative cardiopulmonary toxicity after trimodality therapy for esophageal cancer.Frontiers in oncology · 2023Article
- Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer.JTO clinical and research reports · 2022Article
- Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy.International journal of particle therapy · 2022Article
- Assessment of a diaphragm override strategy for robustly optimized proton therapy planning for esophageal cancer patients.Medical physics · 2021Article
- Patterns of Proton Beam Therapy Use in Clinical Practice between 2007 and 2019 in Korea.Cancer research and treatment · 2021Article
- Normal Tissue Injury Induced by Photon and Proton Therapies: Gaps and Opportunities.International journal of radiation oncology, biology, physics · 2021Review
- Dose distribution effects of spot-scanning proton beam therapy equipped with a multi-leaf collimator for pediatric brain tumors.Oncology letters · 2021Article
- Proton beam radiotherapy for esophagus cancer: state of the art.Journal of thoracic disease · 2020Review
- The Current Evidence on Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma.The Korean journal of thoracic and cardiovascular surgery · 2020Article
- The emerging role of proton therapy for esophagus cancer.Journal of gastrointestinal oncology · 2020Review
- Efficacy of Endoscopic Evaluation of Acute Radiation Esophagitis during Chemoradiotherapy with Proton Beam Therapy Boost for Esophageal Cancer.Digestion · 2020Article
- Dosimetric comparison of distal esophageal carcinoma plans for patients treated with small-spot intensity-modulated proton versus volumetric-modulated arc therapies.Journal of applied clinical medical physics · 2019Article
- Bayesian Semiparametric Joint Regression Analysis of Recurrent Adverse Events and Survival in Esophageal Cancer Patients.The annals of applied statistics · 2019Article
- Proton therapy for small cell lung cancer.Translational lung cancer research · 2018Review
- Utilization of neoadjuvant intensity-modulated radiation therapy and proton beam therapy for esophageal cancer in the United States.Journal of gastrointestinal oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Radiation therapy (RT) plays an essential role in the management of esophageal cancer. Because the esophagus is a centrally located thoracic structure there is a need to balance the delivery of appropriately high dose to the target while minimizing dose to nearby critical structures. Radiation dose received by these critical structures, especially the heart and lungs, may lead to clinically significant toxicities, including pneumonitis, pericarditis, and myocardial infarction. Although technological advancements in photon RT delivery like intensity modulated RT have decreased the risk of such toxicities, a growing body of evidence indicates that further risk reductions are achieved with proton beam therapy (PBT). Herein we review the published dosimetric and clinical PBT literature for esophageal cancer, including motion management considerations, the potential for reirradiation, radiation dose escalation, and ongoing esophageal PBT clinical trials. We also consider the potential cost-effectiveness of PBT relative to photon RT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.