ArticleInternational journal of radiation oncology, biology, physics2016
Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy.
Article in International journal of radiation oncology, biology, physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Influence of age and sex on the relative biological effectiveness of 13-keV/μm carbon ions for lifespan shortening of B6C3F1 Mice.PloS one · 2025Article
- Dosimetric analysis of six whole-breast irradiation techniques in supine and prone positions.Scientific reports · 2024Article
- Particle Therapy for Breast Cancer.Cancers · 2022Review
- Technical Note: validation of a material assignment method for a retrospective study of carbon-ion radiotherapy using Monte Carlo simulation.Journal of radiation research · 2021Article
- Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy.Frontiers in oncology · 2021Article
- Visualized Analysis of Heavy Ion Radiotherapy: Development, Barriers and Future Directions.Frontiers in oncology · 2021Review
- Carbon Ion Radiobiology.Cancers · 2020Review
- Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy.Radiation oncology (London, England) · 2020Article
- Carbon ion radiation therapy in breast cancer: a new frontier.Breast cancer research and treatment · 2020Review
- Carbon Ion Therapy: A Modern Review of an Emerging Technology.Frontiers in oncology · 2020Review
- Carbon ion radiotherapy for inoperable pediatric osteosarcoma.Oncotarget · 2018Article
- Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair.Cancers · 2017Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThis work proposes a theoretical framework that enables comparative risk predictions for second cancer incidence after particle beam therapy for different ion species for individual patients, accounting for differences in relative biological effectiveness (RBE) for the competing processes of tumor initiation and cell inactivation. Our working hypothesis was that use of carbon-ion therapy instead of proton therapy would show a difference in the predicted risk of second cancer incidence in the breast for a sample of Hodgkin lymphoma (HL) patients. METHODS AND MATERIALS: We generated biologic treatment plans and calculated relative predicted risks of second cancer in the breast by using two proposed methods: a full model derived from the linear quadratic model and a simpler linear-no-threshold model.
resultsFor our reference calculation, we found the predicted risk of breast cancer incidence for carbon-ion plans-to-proton plan ratio, <Rc/Rp>, to be 0.75 ± 0.07 but not significantly smaller than 1 (P=.180).
conclusionsOur findings suggest that second cancer risks are, on average, comparable between proton therapy and carbon-ion therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.