Evidence map›Paper›PMID 27084403›Full record

ArticleThe Journal of allergy and clinical immunology2016

Toll-like receptor 2-expressing macrophages are required and sufficient for rhinovirus-induced airway inflammation.

Mingyuan Han, Yutein Chung, Jun Young Hong, Charu Rajput, Jing Lei, Joanna L Hinde, Qiang Chen, Steven P Weng, J Kelley Bentley, Marc B Hershenson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Unveiling the prevalence and impact of silent rhinovirus infection in chronic rhinosinusitis with nasal polyps.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Rhinovirus and asthma: Challenges and opportunities.Reviews in medical virology · 2021
    Review
  11. Article
  12. Review
  13. Rhinovirus Attributes that Contribute to Asthma Development.Immunology and allergy clinics of North America · 2019
    Review
  14. Article
  15. Myristoylated rhinovirus VP4 protein activates TLR2-dependent proinflammatory gene expression.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mingyuan HanDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Yutein ChungDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Jun Young HongDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Mich.
Charu RajputDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Jing LeiDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Joanna L HindeDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Qiang ChenDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Steven P WengDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
J Kelley BentleyDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich.
Marc B HershensonDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Mich. Electronic address: mhershen@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Rhinovirus and Airway Epithelial Cell ResponsesR01HL081420 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2006 to 2014
$3.3M
TLR2 and rhinovirus-induced asthma exacerbationsR01HL134369 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL081420NHLBI NIH HHS R01 HL134369
6 · The paper itself

Abstract

backgroundWe have shown that rhinovirus, a cause of asthma exacerbation, colocalizes with CD68

objectiveWe hypothesize that TLR2

methodsNaive and ovalbumin (OVA)-sensitized and challenged C57BL/6 wild-type and TLR2

resultsRV1B infection of naive wild-type mice induced an influx of airway neutrophils and CD11b

conclusionsTLR2 is required for early inflammatory responses induced by rhinovirus, and TLR2

Indexed as

AnimalsAsthmaCells, CulturedHumansMacrophage ActivationMacrophagesMiceMice, Inbred C57BLMice, KnockoutPicornaviridae InfectionsRhinovirusToll-Like Receptor 2Tlr2 protein, mouseToll-Like Receptor 2Alternative activationasthmaCD11bexacerbationM2 macrophage

Identifiers

PMID27084403
PMCPMC5061583
OpenAlexW2337739154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.