SynthesisInfection2016
Neurotoxocariasis: a systematic literature review.
Synthesis in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2018Pooled it
- Granulomatous Diseases of the CNS: Aetiology, Neuroradiological Features and Clinical Findings.Clinical neuroradiology · 2026Review
- Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain.Nature communications · 2026Article
- Socioeconomic vulnerability associated with toxocariasis exposure in southern Brazil: a One Health approach.Frontiers in public health · 2026Article
- Toxocariasis as an Elderly Zoonosis: Seroprevalence, Neurocognitive Assessment, and Associated Risk Factors in Persons 50 Years and Older.Pathogens (Basel, Switzerland) · 2025Article
- Clinical Spectrum of Toxocariasis: A Retrospective Study From a Tertiary Care Center in Lebanon.Future microbiology · 2025Article
- Infrared live imaging and navigated laser for nematode photocoagulation in a child with diffuse unilateral subacute neuroretinitis (DUSN).American journal of ophthalmology case reports · 2024Article
- The global prevalence ofInternational journal for parasitology. Parasites and wildlife · 2024Article
- Neurobehavioral Disorders and Pathological Changes in the Brain of Mice Are Caused by Chronic Toxocara canis Larval Invasion with Low to Moderate Inoculum.Acta parasitologica · 2024Article
- Efficacy of artemether against toxocariasis in mice: parasitological and immunopathological changes in brain, liver, and lung.Pathogens and global health · 2024Article
- Effects of metformin on parasitological, pathological changes in the brain and liver and immunological aspects during visceral toxocariasis in mice.Parasitology research · 2023Article
- Emerging and Re-Emerging Parasitic Infections of the Central Nervous System (CNS) in Europe.Infectious disease reports · 2023Review
- Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection.International journal of environmental research and public health · 2023Review
- A case report of spinal toxocariasis with extensive tumor-like involvement.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Case report: Probable toxocariasis in a Swiss adult patient with hypereosinophilic syndrome and multiorgan involvement.SAGE open medical case reports · 2023Article
- Lung Lipidomic Alterations in Beagle Dogs Infected withAnimals : an open access journal from MDPI · 2022Article
- Association between toxocariasis seropositivity and serointensity and cognitive function in older U.S. adults.Folia parasitologica · 2022Article
- Prevalence ofVeterinary sciences · 2022Article
- Therapy and Prevention for Human Toxocariasis.Microorganisms · 2022Article
- Toxocariasis affecting brain stem and skull base.BMC infectious diseases · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeToxocariasis is a widespread zoonosis, which may result in central nervous system injury.
methodsWe conducted a systematic literature review in MEDLINE, SciELO, ScienceDirect and Google Scholar up to April 2015 using a combination of the following search terms: "neurotoxocariasis" or "neurotoxocarosis", "toxocariasis" or "toxocarosis" and "cerebral" or "neurologic".
resultsOne hundred cases of neurotoxocariasis were identified in literature. The majority of patients were male (58 %), with a median age of 42 years. The predominant clinical pictures were myelitis (60 %), encephalitis (47 %) and/or meningitis (29 %). Fever was inconstant (23 %). The suspected mode of transmission, mentioned in only 49 % of cases, was mainly contact with dogs and/or cats (67 %) and ingestion of contaminated food (31 %). Diagnostic imaging examinations found hypodense lesions in cerebral scanner sequences and hyperintense lesions in cerebral MRI T2-weighted sequences in 65 and 57 % of encephalitis cases respectively, and in 92 % of myelitis cases in medullary MRI T2-weighted sequences. The detection of antibodies against Toxocara spp. was almost constant in blood and cerebrospinal fluid (CSF), 99 and 93 %, respectively. The two most commonly used drugs were corticosteroids (72 %) and/or albendazole (68 %) for a period of at least 3 weeks, which often needed to be repeated. Despite a low mortality rate (6 %), complete remission was observed in only 40 % of cases.
conclusionsNeurotoxocariasis, a completely preventable zoonosis, could lead to severe sequelae failing prompt diagnosis. A compatible clinical picture, presence of risk factors, blood eosinophilia and high titers of antibodies against Toxocara spp. in CSF should alert physicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.