ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2016
Peripheral fibroblast metabolic pathway alterations in juvenile rhesus monkeys undergoing long-term fluoxetine administration.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Understanding ayahuasca effects in major depressive disorder treatment through in vitro metabolomics and bioinformatics.Analytical and bioanalytical chemistry · 2023Article
- Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling.Zoological research · 2023Article
- Untargeted Metabolomics Reveals Antidepressant Effects in a Marine Photosynthetic Organism: The DiatomBiology · 2022Article
- Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.Molecular psychiatry · 2021Article
- Lipid metabolism is associated with temperament, corticosteroid, and hematological measures in infant rhesus monkeys (Zoological research · 2020Article
- Serotonin Transporter Binding Potentials in Brain of Juvenile Monkeys 1 Year After Discontinuation of a 2-Year Treatment With Fluoxetine.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Fluoxetine Administration in Juvenile Monkeys: Implications for Pharmacotherapy in Children.Frontiers in pediatrics · 2018Review
- Cognitive performance of juvenile monkeys after chronic fluoxetine treatment.Developmental cognitive neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We report on biochemical pathways perturbed upon chronic fluoxetine administration to juvenile macaques using global metabolomics analyses of fibroblasts derived from skin biopsies. After exposure to tissue culture conditions confounding environmental factors are eliminated and identification of metabolites whose levels are affected by the drug become apparent with a better signal-to-noise ratio compared to data obtained from plasma and cerebrospinal fluid (CSF). Levels of more than 200 metabolites were analyzed to interrogate affected molecular pathways and identify biomarkers of drug response. In addition, we have correlated the metabolomics results with monoamine oxidase (MAOA) genotype and impulsivity behavioral data. Affected pathways include Purine and Pyrimidine metabolisms that have been previously implicated to contribute to neuropsychiatric disorders.
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Registered trials
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