Evidence map›Paper›PMID 27084287›Full record

ArticleBMJ open2016

Weekly miscarriage rates in a community-based prospective cohort study in rural western Kenya.

Stephanie Dellicour, George Aol, Peter Ouma, Nicole Yan, Godfrey Bigogo, Mary J Hamel, Deron C Burton, Martina Oneko, Robert F Breiman, Laurence Slutsker and 8 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  14. Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir.Journal of acquired immune deficiency syndromes (1999) · 2019
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  15. Safety of atovaquone-proguanil during pregnancy.Journal of travel medicine · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Stephanie DellicourLiverpool School of Tropical Medicine, Liverpool, UK.
George AolKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Peter OumaKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Nicole YanLiverpool School of Tropical Medicine, Liverpool, UK.
Godfrey BigogoKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Mary J HamelCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Deron C BurtonCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Martina OnekoKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Robert F BreimanGlobal Health Institute, Emory University, Atlanta, Georgia, USA.
Laurence SlutskerCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Daniel FeikinCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Simon KariukiKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Frank OdhiamboKenya Medical Research Institute Centre for Global Health Research, Kisumu, Kenya.
Gregory CalipPharmacy Systems, Outcomes and Policy Department, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID http://orcid.org/0000-0002-7744-3518
Andreas StergachisDepartments of Pharmacy and Global Health, Schools of Pharmacy and Public Health, University of Washington, Seattle, Washington, USA.
Kayla F LasersonCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Feiko O ter KuileLiverpool School of Tropical Medicine, Liverpool, UK.
Meghna DesaiCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USKenya Medical Research Institute · KELiverpool School of Tropical Medicine · GBEmory University · USUniversity of Illinois Chicago · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInformation on adverse pregnancy outcomes is important to monitor the impact of public health interventions. Miscarriage is a challenging end point to ascertain and there is scarce information on its rate in low-income countries. The objective was to estimate the background rate and cumulative probability of miscarriage in rural western Kenya.

designThis was a population-based prospective cohort. PARTICIPANTS AND

settingWomen of childbearing age were followed prospectively to identify pregnancies and ascertain their outcomes in Siaya County, western Kenya. The cohort study was carried out in 33 adjacent villages under health and demographic surveillance. OUTCOME MEASURE: Miscarriage.

resultsBetween 2011 and 2013, among 5536 women of childbearing age, 1453 pregnancies were detected and 1134 were included in the analysis. The cumulative probability was 18.9%. The weekly miscarriage rate declined steadily with increasing gestation until approximately 20 weeks. Known risk factors for miscarriage such as maternal age, gravidity, occupation, household wealth and HIV infection were confirmed.

conclusionsThis is the first report of weekly miscarriage rates in a rural African setting in the context of high HIV and malaria prevalence. Future studies should consider the involvement of community health workers to identify the pregnancy cohort of early gestation for better data on the actual number of pregnancies and the assessment of miscarriage.

Indexed as

Abortion, SpontaneousDeveloping CountriesRural PopulationAdolescentAdultAge FactorsFemaleGravidityHIV InfectionsHumansKenyaPregnancyPregnancy ComplicationsPrevalenceProspective StudiesRisk FactorsKenyaMiscarriageprospective cohortratesub-Saharan Africa

Identifiers

PMID27084287
PMCPMC4838731
OpenAlexW2336788769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.