ArticleJournal of the neurological sciences2016
Blinded search for varicella zoster virus in giant cell arteritis (GCA)-positive and GCA-negative temporal arteries.
Article in Journal of the neurological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The microbiome in autoimmune rheumatic disease.Best practice & research. Clinical rheumatology · 2020Review
- Mechanism and biomarkers in aortitis--a review.Journal of molecular medicine (Berlin, Germany) · 2020Review
- Varicella Zoster Virus in Giant Cell Arteritis: A Review of Current Medical Literature.Neuro-ophthalmology (Aeolus Press) · 2019Review
- Identification of Herpes Zoster-Associated Temporal Arteritis Among Cases of Giant Cell Arteritis.American journal of ophthalmology · 2018Article
- Profile of tocilizumab and its potential in the treatment of giant cell arteritis.Eye and brain · 2018Review
- Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Herpes Zoster as a Risk Factor for Incident Giant Cell Arteritis.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Is chickenpox so bad, what do we know about immunity to varicella zoster virus, and what does it tell us about the future?The Journal of infection · 2017Review
- Giant cell arteritis: pathogenic mechanisms and new potential therapeutic targets.BMC rheumatology · 2017Review
- Bioinformatic analysis reveals new determinants of antigenic 14-3-3 proteins and a novel antifungal strategy.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Recent analysis of archived temporal arteries (TAs) acquired from 13 pathology laboratories in the US, Canada, Iceland, France, Germany and Israel from patients with pathologically-verified giant cell arteritis (GCA-positive) and TAs from patients with clinical features and laboratory abnormalities of GCA but whose TAs were pathologically negative (GCA-negative) revealed VZV antigen in most TAs from both groups. Despite formalin-fixation, VZV DNA was also found in many VZV-antigen positive sections that were scraped, subjected to DNA extraction, and examined by PCR with VZV-specific primers. Importantly, in past studies, the pathological diagnosis (GCA-positive or -negative) was known to the neurovirology laboratory. Herein, GCA-positive and GCA-negative TAs were provided by an outside institution and examined by 4 investigators blinded to the pathological diagnoses. VZV antigen was found in 3/3 GCA-positive TAs and in 4/6 GCA-negative TAs, and VZV DNA in 1/3 VZV antigen-positive, GCA-positive TAs and in 3/4 VZV antigen-positive, GCA-negative TAs. VZV DNA was also detected in one GCA-negative, VZV-antigen negative TA. Overall, the detection of VZV antigen in 78% of GCA-positive and GCA-negative TAs is consistent with previous reports on the prevalence of VZV antigen in patients with clinically suspect GCA.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.