Evidence map›Paper›PMID 27083898›Full record

ArticlePediatric surgery international2016

Patients exposed to diagnostic head and neck radiation for the management of shunted hydrocephalus have a significant risk of developing thyroid nodules.

Jennifer H Aldrink, Brent Adler, Jesse Haines, Daniel Watkins, Mika Matthews, Lacey Lubeley, Wei Wang, Denis R King

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Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Contemporary Thyroid Nodule Evaluation and Management.The Journal of clinical endocrinology and metabolism · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jennifer H AldrinkDivision of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA. Jennifer.aldrink@nationwidechildrens.org.
Brent AdlerDepartment of Radiology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Jesse HainesThe Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Daniel WatkinsDivision of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA.
Mika MatthewsDivision of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA.
Lacey LubeleyDepartment of Radiology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Wei WangDepartment of Biostatistics, Nationwide Children's Hospital, Columbus, OH, USA.
Denis R KingDivision of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA.
Nationwide Children's Hospital · USThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExternal radiation to the head and neck can lead to an increased incidence of thyroid nodules. We investigated whether patients requiring repeated head and neck imaging for the management of shunted hydrocephalus had a higher incidence of ultrasound-detected thyroid nodules compared to reports of comparable age.

methodsPatients treated at our institution for shunted hydrocephalus from 1990 to 2003 were contacted. Enroled patients underwent a thyroid ultrasound. Demographic data and radiation exposure history were obtained retrospectively.

resultsThyroid nodules were identified sonographically in 15/112 patients (13.6 %). Patients with thyroid nodules were older (mean 24.3 ± 7.6 years) than those without (mean 18.4 ± 8.0 years) (p = 0.005). Those with a detectable thyroid nodule had a longer follow up time compared to those who did not (mean 21.9 ± 5.5 vs. 15.1 ± 7 years, respectively) (p = 0.018).

conclusionPatients with shunted hydrocephalus are exposed to substantial head and neck radiation from diagnostic imaging and have a higher incidence of thyroid nodules detected by ultrasonography. These patients should be provided ongoing surveillance for detection of thyroid nodules and the possibility of malignancy.

Indexed as

Cerebrospinal Fluid ShuntsAdolescentAdultFemaleHumansHydrocephalusIncidenceMaleRadiation DosageRadiation InjuriesRetrospective StudiesRisk FactorsThyroid NoduleTomography, X-Ray ComputedUnited StatesYoung AdultHydrocephalusRadiationThyroid malignancyThyroid nodule

Identifiers

PMID27083898
OpenAlexW2337025543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.