ArticleSchizophrenia research2016
Differential sensory fMRI signatures in autism and schizophrenia: Analysis of amplitude and trial-to-trial variability.
Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Autism spectrum disorder and schizophrenia: An updated conceptual review.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Assessment and correlates of autistic symptoms in Schizophrenia Spectrum Disorders measured with the PANSS Autism Severity Score: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Auditory discomfort and visual sensitivity.Vision research · 2025Article
- Identifying overlapping and distinctive traits of autism and schizophrenia using machine learning classification.Cognitive neuropsychiatry · 2025Article
- Pattern glare sensitivity distinguishes subclinical autism and schizotypy.Cognitive neuropsychiatry · 2024Article
- An evaluation of the German version of the Sensory Perception Quotient from an expert by experience perspective.Frontiers in psychology · 2024Article
- Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.Journal of autism and developmental disorders · 2023Article
- People with high schizotypy experience more illusions in the Pattern Glare Test: Consistent with the hyperexcitability hypothesis.The European journal of neuroscience · 2023Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.Research in autism spectrum disorders · 2022Article
- Evidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder.Communications biology · 2021Article
- Visual Influences on Auditory Behavioral, Neural, and Perceptual Processes: A Review.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Trial-to-Trial Variability in Electrodermal Activity to Odor in Autism.Autism research : official journal of the International Society for Autism Research · 2020Article
- Increasing endogenous activity of NMDARs on GABAergic neurons increases inhibition, alters sensory processing and prevents noise-induced tinnitus.Scientific reports · 2020Article
- Greater Individual Variability in Functional Brain Activity during Working Memory Performance in young people with Autism and Executive Function Impairment.NeuroImage. Clinical · 2020Article
- Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders.Frontiers in psychiatry · 2020Review
- White matter structure in schizophrenia and autism: Abnormal diffusion across the brain in schizophrenia.Neuropsychologia · 2019Article
- Increased scale-free dynamics in salience network in adult high-functioning autism.NeuroImage. Clinical · 2019Article
- Sensory Abnormalities in Autism Spectrum Disorders: A Focus on the Tactile Domain, From Genetic Mouse Models to the Clinic.Frontiers in psychiatry · 2019Review
- The Glasgow Sensory Questionnaire: Validation of a French Language Version and Refinement of Sensory Profiles of People with High Autism-Spectrum Quotient.Journal of autism and developmental disorders · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Autism and schizophrenia share multiple phenotypic and genotypic markers, and there is ongoing debate regarding the relationship of these two disorders. To examine whether cortical dynamics are similar across these disorders, we directly compared fMRI responses to visual, somatosensory and auditory stimuli in adults with autism (N=15), with schizophrenia (N=15), and matched controls (N=15). All participants completed a one-back letter detection task presented at fixation (to control attention) while task-irrelevant sensory stimulation was delivered to the different modalities. We focused specifically on the response amplitudes and the variability in sensory fMRI responses of the two groups, given the evidence of greater trial-to-trial variability in adults with autism. Both autism and schizophrenia individuals showed weaker signal-to-noise ratios (SNR) in sensory-evoked responses compared to controls (d>0.42), but for different reasons. For the autism group, the fMRI response amplitudes were indistinguishable from controls but were more variable trial-to-trial (d=0.47). For the schizophrenia group, response amplitudes were smaller compared to autism (d=0.44) and control groups (d=0.74), but were not significantly more variable (d<0.29). These differential group profiles suggest (1) that greater trial-to-trial variability in cortical responses may be specific to autism and is not a defining characteristic of schizophrenia, and (2) that blunted response amplitudes may be characteristic of schizophrenia. The relationship between the amplitude and the variability of cortical activity might serve as a specific signature differentiating these neurodevelopmental disorders. Identifying the neural basis of these responses and their relationship to the underlying genetic bases may substantially enlighten the understanding of both disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.