ArticleMicrobes and infection
CD8(+) T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite.
Article in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Defining neuronal responses to the neurotropic parasitemSphere · 2025Article
- The Absence of CXCL10 Activity Does Not Affect the Capability of CD8Microorganisms · 2024Article
- A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice.Journal of neuroinflammation · 2024Article
- A Lower Dose of Infection Generates a Better Long-Term Immune Response against Toxoplasma gondii.ImmunoHorizons · 2023Article
- Dense granule protein 3 ofFrontiers in immunology · 2023Article
- A pathway to cure chronic infection with Toxoplasma gondii through immunological intervention.Parasitology international · 2021Review
- Dynamic Expressions of TIGIT on Splenic T Cells and TIGIT-Mediated Splenic T Cell Dysfunction of Mice With ChronicFrontiers in microbiology · 2021Article
- Expression of TIGIT in splenic and circulatory T cells from mice acutely infected with Toxoplasma gondii.Parasite (Paris, France) · 2021Article
- Article
- A review on inactivation methods of Toxoplasma gondii in foods.Pathogens and global health · 2018Review
- PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii.Infection and immunity · 2018Article
- Determination of a Key Antigen for Immunological Intervention To Target the Latent Stage ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Our previous study demonstrated that CD8(+) T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8(+) immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8(+) T cells removed cysts of a type III strain. Therefore, CD8(+) T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.