ArticleHippocampus2016
Reactivation during encoding supports the later discrimination of similar episodic memories.
Article in Hippocampus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Identifying causal subsequent memory effects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neural Reinstatement of Overlapping Memories in Young and Older Adults.Journal of cognitive neuroscience · 2022Article
- Article
- Cortical Overlap and Cortical-Hippocampal Interactions Predict Subsequent True and False Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dissociation of the Perirhinal Cortex and Hippocampus During Discriminative Learning of Similar Objects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Time-resolved neural reinstatement and pattern separation during memory decisions in human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- NEVER forget: negative emotional valence enhances recapitulation.Psychonomic bulletin & review · 2018Review
- Replicability of representational similarity and its role in successful memory retrieval.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Episodic memory is characterized by remembering events as unique combinations of features. Even when some features of events overlap, we are later often able to discriminate among them. Here we ask whether hippocampally mediated reactivation of an earlier event when a similar one occurs supports subsequent memory that two similar but not identical events occurred (mnemonic discrimination). In two experiments, participants viewed objects (Experiment 1) or scenes (Experiment 2) during functional MRI (fMRI). After scanning, participants had to remember whether repeated items had been identical or similar. In Experiment 2, representational similarity between the 1st and 2nd presentation predicted participants' ability to remember that the presentations were different, suggesting that the first item was reactivated while viewing the second. A similar but weaker result was found in Experiment 1 that did not survive correction for multiple comparisons. Furthermore, both experiments yielded evidence that the hippocampus was involved in reactivation; hippocampal pattern similarity (and, in Experiment 2, hippocampal activity during the 2nd presentation) correlated with pattern similarity in several regions of visual cortex. These results provide the first fMRI evidence that hippocampally mediated reactivation contributes to the later memory that two similar, but different events occurred. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.