ArticleJournal of aerosol medicine and pulmonary drug delivery2016
Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates.
Article in Journal of aerosol medicine and pulmonary drug delivery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 92 citations in OpenAlex.
- Direct Numerical Simulations of Inhalation in a 23-Generation Lung Model.International journal for numerical methods in biomedical engineering · 2026Article
- CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review.Pharmaceutical research · 2026Review
- The Advanced Integrated Respiratory (AIR) Model: Comparative Analysis of Salbutamol Sulphate Deposition from pMDI, DPI, and Nebuliser Versus the NGI.Pharmaceutical research · 2026Article
- Using Lung Regional Deposition Modeling as Model-Integrated Evidence for Locally Acting Orally Inhaled Drug Products.Pharmaceutical research · 2025Review
- Numerical Investigation to Improve Pulmonary Drug Delivery via Dry Powder Inhalers: A Review of In-Silico Modeling.Pharmaceutical research · 2025Review
- Modeling aerosol bolus inhalations in the human lung with the Multiple Path Particle Deposition model: Comparison with experimental data.Journal of aerosol science · 2025Article
- Article
- The effects of airway disease on the deposition of inhaled drugs.Expert opinion on drug delivery · 2024Review
- Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels.Journal of aerosol science · 2024Article
- Automated bidirectional coupling of multiscale models of aerosol dosimetry: validation with subject-specific deposition data.Journal of aerosol science · 2023Article
- Mechanistic modeling of generic orally inhaled drug products: A workshop summary report.CPT: pharmacometrics & systems pharmacology · 2023Review
- Evaluation of the Polyhedral Mesh Style for Predicting Aerosol Deposition in Representative Models of the Conducting Airways.Journal of aerosol science · 2022Article
- New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Efficient bi-directional coupling of 3D Computational Fluid-Particle Dynamics and 1D Multiple Path Particle Dosimetry lung models for multiscale modeling of aerosol dosimetry.Journal of aerosol science · 2021Article
- [Numerical simulation on the deposition characteristics of inhaled particles in human pulmonary acinus region under the influence of multi-factors].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition.International journal of environmental research and public health · 2020Review
- Patient-specific modeling of aerosol delivery in healthy and asthmatic adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2019Review
- MultiscaleCurrent opinion in biomedical engineering · 2019Article
- Impact of endoscopic craniofacial resection on simulated nasal airflow and heat transport.International forum of allergy & rhinology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe objective of this study was to compare aerosol deposition predictions of a new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) considered across multiple inhalation waveforms, which affect both the particle size distribution (PSD) and particle deposition.
methodsThe Novolizer DPI with a budesonide formulation was selected based on the availability of 2D gamma scintigraphy data in humans for three different well-defined inhalation waveforms. Initial in vitro cascade impaction experiments were conducted at multiple constant (square-wave) particle sizing flow rates to characterize PSDs. The whole-airway CFD modeling approach implemented the experimentally determined PSDs at the point of aerosol formation in the inhaler. Complete characteristic airway geometries for an adult were evaluated through the lobar bronchi, followed by stochastic individual pathway (SIP) approximations through the tracheobronchial region and new acinar moving wall models of the alveolar region.
resultsIt was determined that the PSD used for each inhalation waveform should be based on a constant particle sizing flow rate equal to the average of the inhalation waveform's peak inspiratory flow rate (PIFR) and mean flow rate [i.e., AVG(PIFR, Mean)]. Using this technique, agreement with the in vivo data was acceptable with <15% relative differences averaged across the three regions considered for all inhalation waveforms. Defining a peripheral to central deposition ratio (P/C) based on alveolar and tracheobronchial compartments, respectively, large flow-rate-dependent differences were observed, which were not evident in the original 2D in vivo data.
conclusionsThe agreement between the CFD predictions and in vivo data was dependent on accurate initial estimates of the PSD, emphasizing the need for a combination in vitro-in silico approach. Furthermore, use of the AVG(PIFR, Mean) value was identified as a potentially useful method for characterizing a DPI aerosol at a constant flow rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.