Evidence map›Paper›PMID 27082036›Full record

Trial reportHuman vaccines & immunotherapeutics2016

Impact of a multi-component antenatal vaccine promotion package on improving knowledge, attitudes and beliefs about influenza and Tdap vaccination during pregnancy.

Allison T Chamberlain, Katherine Seib, Kevin A Ault, Eli S Rosenberg, Paula M Frew, Marielysse Cortes, Ellen A S Whitney, Ruth L Berkelman, Walter A Orenstein, Saad B Omer

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01761799 (Protecting Pregnant Women From Infectious Diseases), which is not on this map. Cited by 11 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01761799 nacompletednot on this map

Protecting Pregnant Women From Infectious Diseases: a Cluster Randomized Evaluation of the Comprehensive "P3" Intervention Package Within Obstetric Practices in Georgia

TypeinterventionalSponsorEmory UniversityRan2012 to 2015Enrolled330ConditionsInfluenza, PertussisArmsP3 Vaccine Promotion Package.
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 5 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Enhancing uptake of influenza maternal vaccine.Expert review of vaccines · 2019
    Review
  9. Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Allison T Chamberlaina Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Katherine Seibb Division of Infectious Diseases, School of Medicine , Emory University , Atlanta , GA , USA.
Kevin A Aultc Department of Gynecology and Obstetrics, School of Medicine , Emory University , Atlanta , GA , USA.
Eli S Rosenberga Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Paula M Frewd Department of Medicine , Division of Infectious Diseases , Decatur , GA , USA.
Marielysse Cortese Hubert Department of Global Health , Rollins School of Public Health , Atlanta , GA , USA.
Ellen A S Whitneya Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Ruth L Berkelmana Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Walter A Orensteinb Division of Infectious Diseases, School of Medicine , Emory University , Atlanta , GA , USA.
Saad B Omere Hubert Department of Global Health , Rollins School of Public Health , Atlanta , GA , USA.
Emory University · USGeorgia Department of Public Health · USOffice of Infectious Diseases · US

Funding

OPHPR CDC HHS P01 TP000300
6 · The paper itself

Abstract

objectiveUnderstanding whether interventions designed to improve antenatal vaccine uptake also change women's knowledge about vaccination is critical for improving vaccine coverage. This exploratory study evaluates the effectiveness of a multi-component influenza and tetanus, diphtheria, and acellular pertussis (Tdap) vaccine promotion package on improving women's knowledge, attitudes and beliefs toward antenatal vaccination. STUDY

designIn 2012/2013 a cluster-randomized trial was conducted to test the effectiveness of a vaccine promotion package on improving antenatal vaccine coverage. Participants included 325 unvaccinated pregnant women from 11 obstetric practices in Georgia. Eleven health beliefs measures were assessed at baseline and 2-3 months post-partum. Outcomes were differences in proportions of women citing favorable responses to each measure between study groups at follow-up.

resultsWomen enrolled in their third trimester had a higher probability of asking family members to vaccinate to protect the infant if they were in the intervention group versus the control group (36% vs. 22%; risk ratio [RR] = 1.65, 95% confidence interval [CI]: 1.21, 2.26). A similar association was not observed among women enrolled before their third trimester (39% vs. 44%; RR = 0.93, 95% CI: 0.50, 1.73). There were no other significant differences at follow-up between study groups.

conclusionsWhile exposure to the intervention package may have raised awareness that vaccinating close contacts can protect an infant, there is little evidence that the package changed women's attitudes and beliefs toward antenatal vaccination. Future research should ensure adequate exposure to the intervention and consider study design aspects including power to assess changes in secondary outcomes, discriminatory power of response options, and social desirability bias. This study is registered with clinicaltrials.gov, study ID NCT01761799.

Indexed as

Health Knowledge, Attitudes, PracticePatient Acceptance of Health CareAdultBehavior TherapyDiphtheria-Tetanus-acellular Pertussis VaccinesFemaleGeorgiaHumansInfantInfant, NewbornInfluenza VaccinesPilot ProjectsPregnancyPrenatal CareVaccinationDiphtheria-Tetanus-acellular Pertussis VaccinesInfluenza Vaccinesantenatal vaccinationinfluenzarandomized clinical trialTdap

Identifiers

PMID27082036
PMCPMC4994750
OpenAlexW2340271063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.