ArticlePediatric research2016
Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Oxygen saturation targeting by pulse oximetry in the extremely low gestational age neonate: a quixotic quest.Current opinion in pediatrics · 2017Pooled it
- Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach.Clinical pharmacokinetics · 2025Article
- Retinopathy of prematurity in the era of precision neonatology: from risk stratification to targeted therapies.World journal of pediatrics : WJP · 2025Article
- Efficacy of supplemental oxygen in reducing the need for laser or intravitreal bevacizumab in preterm infants with stage 2 retinopathy of prematurity.BMC ophthalmology · 2024Article
- Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity.Italian journal of pediatrics · 2024Article
- ROP: 80 Years after Its Detection - Where Do We Stand and How Long Will We Continue to Laser?Neonatology · 2024Review
- Latest Trends in Retinopathy of Prematurity: Research on Risk Factors, Diagnostic Methods and Therapies.International journal of general medicine · 2023Review
- Development and Validation of a Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity.JAMA network open · 2022Article
- Article
- 80 Years of vision: preventing blindness from retinopathy of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Thresholds for oximetry alarms and target range in the NICU: an observational assessment based on likely oxygen tension and maturity.BMC pediatrics · 2020Observational
- Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity.JAMA ophthalmology · 2019Article
- Reduced rate of treated retinopathy of prematurity after implementing lower oxygen saturation targets.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Article
- Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity.Acta paediatrica (Oslo, Norway : 1992) · 2018Article
- Noninvasive high-frequency oscillatory ventilation versus bi-level positive pressure ventilation in premature infants with respiratory failure: A retrospective study.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe compared the incidence of severe retinopathy of prematurity (ROP) and need for laser treatment before and after implementing graded pulse oximeter oxygen saturation (SpO2) targets in extremely preterm infants. Mortality and other secondary outcomes were compared.
methodsBefore 2002, we used 90-94% as the SpO2 target in infants 24(0/7)-27(6/7)wk gestation and birth weight <1,000 g until 35(6/7) wk postmenstrual age (PMA). We implemented graded SpO2 targets based on vaso-obliterative and vaso-proliferative phases of ROP in 2002. Group 1 (1995-2001) before, and Group 2 (2003-2010) after implementation of graded SpO2 targets based on PMA (83-89% until 32(6/7) wk, 90-94% until 35(6/7) wk and >94% at ≥ 36 wk PMA).
resultsThere were 267 patients in Group 1 and 220 in Group 2. There was no significant difference in birth weight or gestational age. Severe ROP (adjusted OR: 0.18, 95% CI: 0.11, 0.30; P < 0.001) and laser surgery rates (adjusted OR: 0.31, 95% CI: 0.18, 0.52; P < 0.001) decreased significantly in Group 2. There was no difference in mortality (adjusted OR: 0.74, 95% CI: 0.37, 1.49; P = 0.40).
conclusionIn this retrospective cohort study, implementation of graded SpO2 targets decreased severe ROP and need for laser therapy, without increasing mortality.
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