Evidence map›Paper›PMID 27081717›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2016

Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.

Jean-Charles Nault, Iadh Mami, Tiziana La Bella, Shalini Datta, Sandrine Imbeaud, Andrea Franconi, Maxime Mallet, Gabrielle Couchy, Eric Letouzé, Camilla Pilati and 9 more

Open access · hybridAbstract readLetterComment
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Gene therapy for liver diseases - progress and challenges.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Genomics of Viral Hepatitis-Associated Liver Tumors.Journal of clinical medicine · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Emerging Issues in AAV-MediatedMolecular therapy. Methods & clinical development · 2018
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 1 country.

Jean-Charles NaultINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Iadh MamiINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Tiziana La BellaINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Shalini DattaINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Sandrine ImbeaudINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Andrea FranconiINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Maxime MalletINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Gabrielle CouchyINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Eric LetouzéINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Camilla PilatiINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Benjamin VerretINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Jean-Frédéric BlancCHU de Bordeaux, Department of Hepatology, Hôpital Saint-André, Bordeaux, France.
Charles BalabaudINSERM, UMR 1053; Université de Bordeaux, Bordeaux, France.
Julien CalderaroINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Alexis LaurentAssistance Publique-Hôpitaux de Paris, Department of Digestive and Hepatobiliary Surgery, CHU Henri Mondor, Créteil, France.
Mélanie LetexierIntegraGen, Evry, France.
Paulette Bioulac-SageINSERM, UMR 1053; Université de Bordeaux, Bordeaux, France.
Fabien CalvoINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Jessica Zucman-RossiINSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
Inserm · FRDélégation Paris 5 · FRUniversité Paris Cité · FRUniversité Sorbonne Paris Nord · FRDélégation Paris 7 · FRGénomique Fonctionnelle des Tumeurs Solides · FRHôpital Pellegrin · FRIntegraGen (France) · FRSorbonne Paris Cité · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, HepatocellularDependovirusGenetic VectorsHumansLiver Neoplasms

Identifiers

PMID27081717
PMCPMC4886947
OpenAlexW2340278309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.