ArticleToxics2015
Comparison of Neurological Function in Males and Females from Two Substrains of C57BL/6 Mice.
Article in Toxics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease.Biomedicines · 2026Review
- Substrain-specific behavioral variation in female C57BL/6 and C57BL/10 mice.Frontiers in behavioral neuroscience · 2026Article
- Otolith Deterioration: Factors Affecting Microvascular and Structural Integrity.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Brief introduction in phenotypic and genetic differences of C57BL/6 and BALB/c mice substrains.Animal models and experimental medicine · 2025Review
- Early life outcomes of prenatal exposure to alcohol and synthetic cannabinoids in mice.Drug and alcohol dependence reports · 2025Article
- Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice.bioRxiv : the preprint server for biology · 2025Article
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains.PloS one · 2022Article
- Distinct Age-Specific Effects on Olfactory Associative Learning in C57BL/6 Substrains.Frontiers in behavioral neuroscience · 2022Article
- Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism.Communications biology · 2021Article
- Consideration of Gut Microbiome in Murine Models of Diseases.Microorganisms · 2021Review
- Substrains matter in phenotyping of C57BL/6 mice.Experimental animals · 2021Review
- Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction.Journal of bioenergetics and biomembranes · 2021Article
- Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains.Scientific reports · 2021Article
- Behavioral tests assessing neuropsychiatric phenotypes in adolescent mice reveal strain- and sex-specific effects.Scientific reports · 2020Article
- Experiments done in Black-6 mice: what does it mean?Lab animal · 2019Article
- Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex.Neurochemical research · 2019Article
- C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in theEpilepsia open · 2019Article
- Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.Genes & nutrition · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The C57BL/6 (B6) mouse is the background strain most frequently used for genetically-modified mice. Previous studies have found significant behavioral and genetic differences between the B6J (The Jackson Laboratory) and B6N substrains (National Institutes of Health); however, most studies employed only male mice. We performed a comprehensive battery of motor function and learning and memory tests on male and female mice from both substrains. The B6N male mice had greater improvement in the rotarod test. In contrast, B6J female mice had longer latencies to falling from the rotarod. In the Morris water maze (MWM), B6J males had significantly shorter latencies to finding the hidden platform. However, B6N females had significantly shorter path lengths in the reversal and shifted-reduced phases. In open field locomotor activity, B6J males had higher activity levels, whereas B6N females took longer to habituate. In the fear conditioning test, B6N males had a significantly longer time freezing in the new context compared with B6J males, but no significant differences were found in contextual or cued tests. In summary, our findings demonstrate the importance of testing both males and females in neurobehavioral studies. Both factors (sex and substrain) must be taken into account when designing developmental neurotoxicology studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.