Evidence map›Paper›PMID 27081544›Full record

ArticleHuman genome variation2015

CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors.

Yiqun Hu, Kengo Yoshida, John B Cologne, Mayumi Maki, Yukari Morishita, Keiko Sasaki, Ikue Hayashi, Waka Ohishi, Ayumi Hida, Seishi Kyoizumi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genome variation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yiqun HuDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Kengo YoshidaDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
John B CologneDepartment of Statistics, Radiation Effects Research Foundation , Hiroshima, Japan.
Mayumi MakiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Yukari MorishitaDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Keiko SasakiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Ikue HayashiCentral Research Laboratory, Hiroshima University Faculty of Dentistry , Hiroshima, Japan.
Waka OhishiClinical Studies, Radiation Effects Research Foundation , Hiroshima, Japan.
Ayumi HidaDepartment of Clinical Studies, Radiation Effects Research Foundation , Nagasaki, Japan.
Seishi KyoizumiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Yoichiro KusunokiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, University of Tokyo , Tokyo, Japan.
Kei NakachiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Tomonori HayashiDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation , Hiroshima, Japan.
Radiation Effects Research Foundation · JPHiroshima University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a common malignancy worldwide, and chronic inflammation is a risk factor for CRC. In this study, we carried out a cohort study among the Japanese atomic bomb (A-bomb) survivor population to investigate any association between immune- and inflammation-related gene polymorphisms and CRC. We examined the effects of six single-nucleotide polymorphisms of CD14 and IL18 on relative risks (RRs) of CRC. Results showed that RRs of CRC, overall and by anatomic subsite, significantly increased with increasing radiation dose. The CD14-911A/A genotype showed statistically significant higher risks for all CRC and distal CRC compared with the other two genotypes. In addition, the IL18-137 G/G genotype showed statistically significant higher risks for proximal colon cancer compared with the other two genotypes. In phenotype-genotype analyses, the CD14-911A/A genotype presented significantly higher levels of membrane and soluble CD14 compared with the other two genotypes, and the IL18-137 G/G genotype tended to be lower levels of plasma interleukin (IL)-18 compared with the other two genotypes. These results suggest the potential involvement of a CD14-mediated inflammatory response in the development of distal CRC and an IL18-mediated inflammatory response in the development of proximal colon cancer among A-bomb survivors.

Identifiers

PMID27081544
PMCPMC4785571
OpenAlexW2412510748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.