ReviewF1000Research2016
Accessing Nature's diversity through metabolic engineering and synthetic biology.
Review in F1000Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative.ACS synthetic biology · 2025Article
- Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity.Journal of medicinal chemistry · 2023Article
- Designing plant flavonoids: harnessing transcriptional regulation and enzyme variation to enhance yield and diversity.Frontiers in plant science · 2023Review
- Antimicrobial Peptides Controlling Resistant Bacteria in Animal Production.Frontiers in microbiology · 2022Review
- Separation and purification of plant terpenoids from biotransformation.Engineering in life sciences · 2021Review
- Antifouling Activity of Meroterpenes Isolated from the Ascidian Aplidium aff. densum.Marine biotechnology (New York, N.Y.) · 2021Article
- Refining Metabolic Mass Transfer for Efficient Biosynthesis of Plant Natural Products in Yeast.Frontiers in bioengineering and biotechnology · 2021Review
- Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids.Nature communications · 2019Article
- Twenty-first-century chemical odyssey: fuels versus commodities and cell factories versus chemical plants.Microbial biotechnology · 2019Review
- Expanding beyond canonical metabolism: Interfacing alternative elements, synthetic biology, and metabolic engineering.Synthetic and systems biotechnology · 2018Review
- Microbial Platform for Terpenoid Production:Frontiers in microbiology · 2018Article
- Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus.BMC genomics · 2017Article
- Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products.ACS central science · 2017Article
- Using natural products for drug discovery: the impact of the genomics era.Expert opinion on drug discovery · 2017Review
- Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning.Journal of natural products · 2017Article
- Diversifying Natural Products with Promiscuous Glycosyltransferase Enzymes via a Sustainable Microbial Fermentation Approach.Frontiers in chemistry · 2017Article
- Opportunities and challenges for the sustainable production of structurally complex diterpenoids in recombinant microbial systems.Beilstein journal of organic chemistry · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this perspective, we highlight recent examples and trends in metabolic engineering and synthetic biology that demonstrate the synthetic potential of enzyme and pathway engineering for natural product discovery. In doing so, we introduce natural paradigms of secondary metabolism whereby simple carbon substrates are combined into complex molecules through "scaffold diversification", and subsequent "derivatization" of these scaffolds is used to synthesize distinct complex natural products. We provide examples in which modern pathway engineering efforts including combinatorial biosynthesis and biological retrosynthesis can be coupled to directed enzyme evolution and rational enzyme engineering to allow access to the "privileged" chemical space of natural products in industry-proven microbes. Finally, we forecast the potential to produce natural product-like discovery platforms in biological systems that are amenable to single-step discovery, validation, and synthesis for streamlined discovery and production of biologically active agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.