Evidence map›Paper›PMID 27081392›Full record

ReviewImmunity & ageing : I & A2016

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges.

Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox, Giovanni Scapagnini

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunity & ageing : I & A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Sergio DavinelliDepartment of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, Italy.
Michael MaesIMPACT Research Center, Deakin University, Geelong, Australia ; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Graziamaria CorbiDepartment of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, Italy.
Armando ZarrelliDepartment of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Naples, Italy.
Donald Craig WillcoxDepartment of Human Welfare, Okinawa International University, Okinawa, Japan ; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
Giovanni ScapagniniDepartment of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, Italy.
University of Molise · ITDeakin University · AUOkinawa International University · JPUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of plant-derived foods and chemical classes. Over the last decade, remarkable progress has been made to realize that oxidative and nitrosative stress (O&NS) and chronic, low-grade inflammation are major risk factors underlying brain aging. Accumulated data strongly suggest that phytochemicals from fruits, vegetables, herbs, and spices may exert relevant negative immunoregulatory, and/or anti-O&NS activities in the context of brain aging. Despite the translational gap between basic and clinical research, the current understanding of the molecular interactions between phytochemicals and immune-inflammatory and O&NS (IO&NS) pathways could help in designing effective nutritional strategies to delay brain aging and improve cognitive function. This review attempts to summarise recent evidence indicating that specific phytochemicals may act as positive modulators of IO&NS pathways by attenuating pro-inflammatory pathways associated with the age-related redox imbalance that occurs in brain aging. We will also discuss the need to initiate long-term nutrition intervention studies in healthy subjects. Hence, we will highlight crucial aspects that require further study to determine effective physiological concentrations and explore the real impact of dietary phytochemicals in preserving brain health before the onset of symptoms leading to cognitive decline and inflammatory neurodegeneration.

Indexed as

AgingBrainDietInflammationOxidative stressPhytochemicals

Identifiers

PMID27081392
PMCPMC4831196
OpenAlexW2338675929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.