Evidence map›Paper›PMID 27081377›Full record

ArticlePsychiatry investigation2016

Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents.

Veronika Marcincakova Husarova, Silvia Lakatosova, Anna Pivovarciova, Katarina Babinska, Jan Bakos, Jaroslava Durdiakova, Aneta Kubranska, Igor Ondrejka, Daniela Ostatnikova

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023
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  19. Overlapping Molecular Pathways Leading to Autism Spectrum Disorders, Fragile X Syndrome, and Targeted Treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Veronika Marcincakova HusarovaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.; Clinic of Psychiatry, Martin University Hospital and Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Silvia LakatosovaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Anna PivovarciovaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Katarina BabinskaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Jan BakosInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Jaroslava DurdiakovaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Aneta KubranskaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Igor OndrejkaClinic of Psychiatry, Martin University Hospital and Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Daniela OstatnikovaInstitute of Physiology, Medical Faculty Comenius University, Bratislava, Slovakia.
Comenius University Bratislava · SKMartin University Hospital · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOxytocin (OT) has been implicated to play an important role in autism spectrum disorders (ASD) etiology. We aimed to find out the differences in plasma OT levels between children with autism and healthy children, the associations of OT levels with particular autism symptoms and the associations of particular parental autistic traits with their ASD children OT levels.

methodsWe included 19 boys with autism and 44 healthy age-matched boys. OT levels were analyzed by ELISA method. Children with autism were scored by Childhood Autism Rating Scale and Autism Diagnostic Interview (ADI), adjusted research version. Autism Spectrum Quotient (AQ), Systemizing Quotient (SQ) and Empathizing Quotient were completed by parents of children with autism.

resultsChildren with autism had significantly lower plasma OT levels than controls. OT levels positively correlated with ADI Reciprocal Interaction and Communication scores. AQ and SQ of fathers positively correlated with children plasma OT level.

conclusionOur results support the hypothesis of OT deficiency in autism. The "paradoxical" associations of OT levels and social skills in children with autism indicate disturbances at various levels of OT system. We first reported associations of OT levels in children with autism and behavioral measures in fathers indicating that OT abnormalities stay between parental autistic traits and autism symptoms in their children.

Indexed as

AutismAutism spectrum quotientOxytocinParentsSystemizing quotient

Identifiers

PMID27081377
PMCPMC4823192
OpenAlexW2339794795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.