ArticleMolecular vision2016
Mammalian retinal Müller cells have circadian clock function.
Article in Molecular vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Global mapping of BMAL1 protein-DNA interactions in human retinal Müller cells.Molecular vision · 2024Article
- Review
- Article
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- Glial Bmal1 role in mammalian retina daily changes.Scientific reports · 2022Article
- The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.Annual review of cell and developmental biology · 2020Review
- A standardized method to assess the endogenous activity and the light-response of the retinal clock in mammals.Molecular vision · 2020Article
- Circadian regulation in the retina: From molecules to network.The European journal of neuroscience · 2020Review
- The circadian clock geneFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Retinal Circadian Clocks are Major Players in the Modulation of Retinal Functions and Photoreceptor Viability.The Yale journal of biology and medicine · 2019Review
- Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.Investigative ophthalmology & visual science · 2018Review
- Circadian rhythms, refractive development, and myopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2018Review
- Histamine Regulates Molecular Clock Oscillations in Human Retinal Pigment Epithelial CellsFrontiers in endocrinology · 2018Article
- Regulation of molecular clock oscillations and phagocytic activity via muscarinic CaScientific reports · 2017Article
- The Role of Mammalian Glial Cells in Circadian Rhythm Regulation.Neural plasticity · 2017Review
- Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish.Investigative ophthalmology & visual science · 2016Article
- The Retina and Other Light-sensitive Ocular Clocks.Journal of biological rhythms · 2016Review
- Circadian and Dopaminergic Regulation of Fatty Acid Oxidation Pathway Genes in Retina and Photoreceptor Cells.PloS one · 2016Article
- Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration.Oxidative medicine and cellular longevityReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo test whether Müller glia of the mammalian retina have circadian rhythms.
methodsWe used Müller glia cultures isolated from mouse lines or from humans and bioluminescent reporters of circadian clock genes to monitor molecular circadian rhythms. The clock gene dependence of the Müller cell rhythms was tested using clock gene knockout mouse lines or with siRNA for specific clock genes.
resultsWe demonstrated that retinal Müller glia express canonical circadian clock genes, are capable of sustained circadian oscillations in isolation from other cell types, and exhibit unique features of their molecular circadian clock compared to the retina as a whole. Mouse and human Müller cells demonstrated circadian clock function; however, they exhibited species-specific differences in the gene dependence of their clocks.
conclusionsMüller cells are the first mammalian retinal cell type in which sustained circadian rhythms have been demonstrated in isolation from other retinal cells.
Indexed as
Identifiers
27081298PMC4812508W2303447433What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.