Evidence map›Paper›PMID 27081158›Full record

ArticleBiological research for nursing2016

Growth Deficiency in Cystic Fibrosis Is Observable at Birth and Predictive of Early Pulmonary Function.

Rebecca Darrah, Rebecca Nelson, Elizabeth G Damato, Michael Decker, Anne Matthews, Craig A Hodges

Open access · greenAbstract readComparative Study
In one paragraph

Article in Biological research for nursing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Guideline
  2. Evolving nutrition therapy in cystic fibrosis: Adapting to the CFTR modulator era.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  3. Review
  4. Cystic fibrosis-related diabetes and lung disease: an update.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  5. Article
  6. GH-IGF-1 Axis in Children with Cystic Fibrosis.Clinical medicine & research · 2019
    Article
  7. Growth failure and treatment in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca DarrahDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA Co-first authors rjm11@case.edu.
Rebecca NelsonDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA Co-first authors.
Elizabeth G DamatoDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Michael DeckerDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Anne MatthewsDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Craig A HodgesDepartment of Genetics, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Case Western Reserve University · USHealth First · US

Funding

Translational Research in Cystic FibrosisP30DK027651 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L · 1986 to 2014
$15.6M
SMART Center II Brain Behavior Connections in Self Management ScienceP30NR015326 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MOORE, SHIRLEY M · 2014 to 2018
$2.8M
NIDDK NIH HHS P30 DK027651NINR NIH HHS P30 NR015326
6 · The paper itself

Abstract

introductionCystic fibrosis (CF) is a complex disease that includes both pulmonary and gastrointestinal challenges, resulting in decreased weight. Pulmonary symptoms of CF are extremely variable. Greater body mass at an early age is associated with improved pulmonary function, but it is unknown at what age weight becomes predictive of pulmonary disease severity. The purpose of this study was to investigate the relationship between birth weight and pulmonary function in CF.

methodsBirth weight and pulmonary data were obtained. Linear regressions were used to examine the relationship between these two variables. A one-tailed t-test was used to compare birth weights between CF patients and the national average.

resultsBirth weight was significantly lower in babies with CF and correlated with pulmonary disease at ages 6 and 10 years but not with age at which Pseudomonas aeruginosa colonization was observed. DISCUSSION: These data suggest that CF growth deficiency has prenatal origins. Early nutritional intervention for babies with CF and a low birth weight is warranted to maximize pulmonary potential.

Indexed as

Birth WeightEarly DiagnosisGrowth and DevelopmentAdolescentChildChild, PreschoolCystic FibrosisFemaleHumansInfantInfant, NewbornLungMalePredictive Value of TestsRespiratory Function TestsSeverity of Illness Indexbirth weightcystic fibrosisgeneticspediatricsrespiratory

Identifiers

PMID27081158
PMCPMC5942479
OpenAlexW2338261094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.