ReviewGastroenterology report2016
Should perioperative immunonutrition for elective surgery be the current standard of care?
Review in Gastroenterology report, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05568316 (Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomised Controlled Clinical Trial
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Immunonutrition for modifying inflammatory markers and improving clinical outcomes following traumatic brain injury: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- Perioperative Immunonutrition in Patients Undergoing Lung Cancer Surgery: Current Evidence and Future Perspectives.Nutrients · 2026Review
- Prehabilitation and postoperative outcomes in colorectal surgery: an umbrella review.Journal of anesthesia, analgesia and critical care · 2026Review
- Postoperative Vaginal Cuff Healing After Minimally Invasive Surgery for Endometrial Cancer: The Role of Postoperative Immunonutrition.Journal of clinical medicine · 2026Article
- Inpatient Nutritional Considerations in Inflammatory Bowel Disease.Current gastroenterology reports · 2025Review
- Effects of preoperative immunonutritionWorld journal of gastrointestinal surgery · 2025Article
- Targeted nutritional strategies in postoperative care.Anesthesia and pain medicine · 2025Review
- The Surgical Stress Response and Anesthesia: A Narrative Review.Journal of clinical medicine · 2024Review
- Article
- Impact of Immunonutrition on T Cell Activation: A Randomized Control Study in Cardiac Surgery Patients.Acta medica Lituanic · 2021Article
- Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2019Article
- The Effect of Immunonutrition on Veterans Undergoing Major Surgery for Gastrointestinal Cancer.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2018Article
- The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis.Oncotarget · 2017Article
- Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective.Nutrients · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative infectious complications are independently associated with increased hospital length of stay (LOS) and cost and contribute to significant inpatient morbidity. Many strategies such as avoidance of long periods of preoperative fasting, re-establishment of oral feeding as early as possible after surgery, metabolic control and early mobilization have been used to either prevent or reduce the incidence of postoperative infections. Despite these efforts, it remains a big challenge to our current healthcare system to mitigate the cost of postoperative morbidity. Furthermore, preoperative nutritional status has also been implicated as an independent risk factor for postoperative morbidity. Perioperative nutritional support using enteral and parenteral routes has been shown to decrease postoperative morbidity, especially in high-risk patients. Recently, the role of immunonutrition (IMN) in postoperative infectious complications has been studied extensively. These substrates have been found to positively modulate postsurgical immunosuppression and inflammatory responses. They have also been shown to be cost-effective by decreasing both tpostoperative infectious complications and hospital LOS. In this review, we discuss the postoperative positive outcomes associated with the use of perioperative IMN, their cost-effectiveness, current guidelines and future clinical implications.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.