ArticleCirculation2016
Global Electric Heterogeneity Risk Score for Prediction of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Risk Prediction for Sudden Cardiac Death in the General Population: A Systematic Review and Meta-Analysis.International journal of public health · 2024Pooled it
- Blood pressure, hypertension and the risk of sudden cardiac death: a systematic review and meta-analysis of cohort studies.European journal of epidemiology · 2020Pooled it
- Enhancing tertiary cardiology triage with vectorcardiographic features: a machine learning approach using real-world data.Clinics (Sao Paulo, Brazil) · 2026Article
- Anticholinergic medications and out-of-hospital sudden cardiac arrest: a new piece to the puzzle?European heart journal · 2025Article
- Larger spatial ventricular gradient magnitude is associated with higher rates of response to cardiac resynchronization therapy.Heart rhythm O2 · 2025Article
- Time-dependent S-wave areas by 24-hour ECG are correlated with a high risk of sudden cardiac death: ECG prediction model development and validation for SCD risk.Cardiovascular diagnosis and therapy · 2025Article
- Machine learning for sudden cardiac death prediction among older adults using community-based electronic health records.BMC public health · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Article
- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Incidence and risk factors associated with atrioventricular block in the general population: the atherosclerosis risk in communities study and Cardiovascular Health Study.BMC cardiovascular disorders · 2024Article
- Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.European heart journal. Digital health · 2024Article
- Competing risks of monomorphic vs. non-monomorphic ventricular arrhythmias in primary prevention implantable cardioverter-defibrillator recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Feasibility of remote monitoring for fatal coronary heart disease using Apple Watch ECGs.Cardiovascular digital health journal · 2024Article
- Predicting and Recognizing Drug-Induced Type I Brugada Pattern Using ECG-Based Deep Learning.Journal of the American Heart Association · 2024Article
- Possible Mechanisms for Adverse Cardiac Events Caused by Exercise-Induced Hypertension in Long-Distance Middle-Aged Runners: A Review.Journal of clinical medicine · 2024Review
- Dynamic electrocardiogram changes are a novel risk marker for sudden cardiac death.European heart journal · 2024Article
- The incidence, predictors, and causes of cardiac arrest in United States emergency departments.Resuscitation plus · 2024Article
- An ECG-based artificial intelligence model for assessment of sudden cardiac death risk.Communications medicine · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 1 country.
Jonathan W WaksFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Colleen M SitlaniFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Elsayed Z SolimanFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Muammar KabirFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Elyar GhafooriFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Mary L BiggsFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Charles A HenriksonFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Nona SotoodehniaFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Tor Biering-SørensenFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Sunil K AgarwalFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
David S SiscovickFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Wendy S PostFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Scott D SolomonFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Alfred E BuxtonFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Mark E JosephsonFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.).
Larisa G TereshchenkoFrom Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.W., A.E.B., M.E.J.); Cardiovascular Health Research Unit, Division of Cardiology, and Department of Epidemiology(C.M.S., M.L.B., N.S., D.S.S.)and Department of Biostatistics (M.L.B.), University of Washington, Seattle; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (M.K., E.G., C.A.H., L.G.T.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (T.B.-S., S.D.S.); Department of Epidemiology, Internal Medicine and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins School of Public Health, Baltimore, MD (S.K.A.); New York Academy of Medicine, New York (D.S.S.); and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P., L.G.T.). tereshch@ohsu.edu.
Johns Hopkins University · USOregon Health & Science University · USBrigham and Women's Hospital · USUniversity of Washington · USBeth Israel Deaconess Medical Center · USHarvard University · USJohns Hopkins Medicine · USNew York Academy of Medicine · USWake Forest University · US
Funding
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MGenomics of Cardiac Electrical Activity and ArrhythmiaR01HL116747 · NHLBI · UNIVERSITY OF WASHINGTON · PI ARKING, DAN E, SOTOODEHNIA, NONA · 2013 to 2016
$2.8MGenomics of Sudden Cardiac Arrest Among African AmericansR01HL111089 · NHLBI · UNIVERSITY OF WASHINGTON · PI SOTOODEHNIA, NONA · 2012 to 2015
$2.6MRole of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9MNovel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5MCHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
–CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
–CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
–NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL118277NHLBI NIH HHS U01 HL080295NIA NIH HHS R01 AG023629
Abstract
backgroundAsymptomatic individuals account for the majority of sudden cardiac deaths (SCDs). Development of effective, low-cost, and noninvasive SCD risk stratification tools is necessary. METHODS AND
resultsParticipants from the Atherosclerosis Risk in Communities study and Cardiovascular Health Study (n=20 177; age, 59.3±10.1 years; age range, 44-100 years; 56% female; 77% white) were followed up for 14.0 years (median). Five ECG markers of global electric heterogeneity (GEH; sum absolute QRST integral, spatial QRST angle, spatial ventricular gradient [SVG] magnitude, SVG elevation, and SVG azimuth) were measured on standard 12-lead ECGs. Cox proportional hazards and competing risks models evaluated associations between GEH electrocardiographic parameters and SCD. An SCD competing risks score was derived from demographics, comorbidities, and GEH parameters. SCD incidence was 1.86 per 1000 person-years. After multivariable adjustment, baseline GEH parameters and large increases in GEH parameters over time were independently associated with SCD. Final SCD risk scores included age, sex, race, diabetes mellitus, hypertension, coronary heart disease, stroke, and GEH parameters as continuous variables. When GEH parameters were added to clinical/demographic factors, the C statistic increased from 0.777 to 0.790 (P=0.008), the risk score classified 10-year SCD risk as high (>5%) in 7.2% of participants, 10% of SCD victims were appropriately reclassified into a high-risk category, and only 1.4% of SCD victims were inappropriately reclassified from high to intermediate risk. The net reclassification index was 18.3%.
conclusionsAbnormal electrophysiological substrate quantified by GEH parameters is independently associated with SCD in the general population. The addition of GEH parameters to clinical characteristics improves SCD risk prediction.
Indexed as
ElectrocardiographyHeart RateAction PotentialsAdultAgedAged, 80 and overArrhythmias, CardiacCause of DeathDeath, Sudden, CardiacFemaleHeart Conduction SystemHumansIncidenceLinear ModelsMaleMiddle Ageddeath, sudden, cardiacelectrocardiographyelectrophysiologyrisk assessment
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