ReviewJournal of biomedical materials research. Part B, Applied biomaterials2017
The biological response to orthopedic implants for joint replacement. II: Polyethylene, ceramics, PMMA, and the foreign body reaction.
Review in Journal of biomedical materials research. Part B, Applied biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Metal implantation and high-grade osteosarcoma of the femur: a case report and review of the literature.Journal of medical case reports · 2026Review
- From a clinical case to a general methodology to analyze prosthetic joint failure, by micro- and nano-characterization with SEM of intra-tissue wear debris.Applied microscopy · 2025Article
- Osteopontin attenuates the foreign-body response to silicone implants.Nature biomedical engineering · 2025Article
- Multiscale metal-based nanocomposites for bone and joint disease therapies.Materials today. Bio · 2025Review
- Bone cement implantation syndrome in patients with cemented endoprostheses for metastatic bone disease in the femur.Journal of bone oncology · 2025Article
- Prosthetic articulating spacers as a preferred option for two-stage revision arthroplasty in chronic periprosthetic joint infection.Arthroplasty (London, England) · 2025Review
- Bone Regeneration: Mini-Review and Appealing Perspectives.Bioengineering (Basel, Switzerland) · 2025Review
- Editorial: Modern advances in arthroplasty.Frontiers in surgery · 2025Article
- Mid-term radiographic evaluation of a monoblock trabecular metal tibia following total knee arthroplasty in obese and morbidly obese patients.Archives of orthopaedic and trauma surgery · 2024Article
- Clinical, Radiographic, and Patient-Perceived Outcome After Radial Hemi-Wrist Arthroplasty With a New Implant: 20 Cases With 5-Year Follow-up.Hand (New York, N.Y.) · 2024Article
- Gelatin-based nanoparticles and antibiotics: a new therapeutic approach for osteomyelitis?Frontiers in molecular biosciences · 2024Review
- Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis.Frontiers in bioengineering and biotechnology · 2024Review
- A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants.Current research in microbial sciences · 2024Review
- Article
- Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect.Biomimetics (Basel, Switzerland) · 2023Article
- Interaction of Ceramic Implant Materials with Immune System.International journal of molecular sciences · 2023Review
- Exploring the Overlooked Roles and Mechanisms of Fibroblasts in the Foreign Body Response.Advances in wound care · 2023Review
- Nano wear particles and the periprosthetic microenvironment in aseptic loosening induced osteolysis following joint arthroplasty.Frontiers in cellular and infection microbiology · 2023Review
- Innate Immune Response in Orthopedic Implant Failure.Journal of orthopaedics and sports medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Novel evidence-based prosthetic designs and biomaterials facilitate the performance of highly successful joint replacement (JR) procedures. To achieve this goal, constructs must be durable, biomechanically sound, and avoid adverse local tissue reactions. Different biomaterials such as metals and their alloys, polymers, ceramics, and composites are currently used for JR implants. This review focuses on (1) the biological response to the different biomaterials used for TJR and (2) the chronic inflammatory and foreign-body response induced by byproducts of these biomaterials. A homeostatic state of bone and surrounding soft tissue with current biomaterials for JR can be achieved with mechanically stable, infection free and intact (as opposed to the release of particulate or ionic byproducts) implants. Adverse local tissue reactions (an acute/chronic inflammatory reaction, periprosthetic osteolysis, loosening and subsequent mechanical failure) may evolve when the latter conditions are not met. This article (Part 2 of 2) summarizes the biological response to the non-metallic materials commonly used for joint replacement including polyethylene, ceramics, and polymethylmethacrylate (PMMA), as well as the foreign body reaction to byproducts of these materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1685-1691, 2017.
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