Evidence map›Paper›PMID 27080737›Full record

Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2017

Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial.

Robert J Shulman, Emily B Hollister, Kevin Cain, Danita I Czyzewski, Mariella M Self, Erica M Weidler, Sridevi Devaraj, Ruth Ann Luna, James Versalovic, Margaret Heitkemper

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00526903 (Recurrent Abdominal Pain in Children), which is not on this map. Cited by 45 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 6 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00526903 phase2completednot on this map

Recurrent Abdominal Pain in Children

TypeinterventionalSponsorBaylor College of MedicineRan2009 to 2014Enrolled168ConditionsAbdominal Pain, Irritable Bowel SyndromeArmsElimination Diet
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Gut bacteria: an etiological agent in human pathological conditions.Frontiers in cellular and infection microbiology · 2024
    Review
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Robert J ShulmanDepartment of Pediatrics, Baylor College of Medicine; Children's Nutrition Research Center; Texas Children's Hospital. Electronic address: rshulman@bcm.edu.
Emily B HollisterTexas Children's Hospital; Texas Children's Microbiome Center; Department of Pathology and Immunology, Baylor College of Medicine; Department of Pathology, Texas Children's Hospital.
Kevin CainDepartment of Biostatistics and Office of Nursing Research, University of Washington, Seattle, Washington.
Danita I CzyzewskiTexas Children's Hospital; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine.
Mariella M SelfTexas Children's Hospital; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine.
Erica M WeidlerDepartment of Pediatrics, Baylor College of Medicine; Children's Nutrition Research Center; Texas Children's Hospital.
Sridevi DevarajTexas Children's Hospital; Texas Children's Microbiome Center; Department of Pathology and Immunology, Baylor College of Medicine; Department of Pathology, Texas Children's Hospital.
Ruth Ann LunaTexas Children's Hospital; Texas Children's Microbiome Center; Department of Pathology and Immunology, Baylor College of Medicine; Department of Pathology, Texas Children's Hospital.
James VersalovicTexas Children's Hospital; Texas Children's Microbiome Center; Department of Pathology and Immunology, Baylor College of Medicine; Department of Pathology, Texas Children's Hospital.
Margaret HeitkemperDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, Washington.
Baylor College of Medicine · USArkansas Children's Nutrition Center · USTexas Children's Hospital · USUniversity of Washington · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Recurrent Abdominal Pain in ChildrenR01NR005337 · NINR · BAYLOR COLLEGE OF MEDICINE · PI SHULMAN, ROBERT J · 2002 to 2012
$4.3M
NIDDK NIH HHS P30 DK056338NINR NIH HHS R01 NR005337
6 · The paper itself

Abstract

BACKGROUND &

aimsWe sought to determine the efficacy of psyllium fiber treatment on abdominal pain and stool patterns in children with irritable bowel syndrome (IBS). We evaluated effects on breath hydrogen and methane production, gut permeability, and microbiome composition. We also investigated whether psychological characteristics of children or parents affected the response to treatment.

methodsWe performed a randomized, double-blind trial of 103 children (mean age, 13 ± 3 y) with IBS seen at primary or tertiary care settings. After 2 weeks on their habitual diet, children began an 8-day diet excluding carbohydrates thought to cause symptoms of IBS. Children with ≥75% improvement in abdominal pain were excluded (n = 17). Children were assigned randomly to groups given psyllium (n = 37) or placebo (maltodextrin, n = 47) for 6 weeks. Two-week pain and stool diaries were compared at baseline and during the final 2 weeks of treatment. We assessed breath hydrogen and methane production, intestinal permeability, and the composition of the microbiome before and after administration of psyllium or placebo. Psychological characteristics of children were measured at baseline.

resultsChildren in the psyllium group had a greater reduction in the mean number of pain episodes than children in the placebo group (mean reduction of 8.2 ± 1.2 after receiving psyllium vs mean reduction of 4.1 ± 1.3 after receiving placebo; P = .03); the level of pain intensity did not differ between the groups. Psychological characteristics were not associated with response. At the end of the study period, the percentage of stools that were normal (Bristol scale scores, 3-5), breath hydrogen or methane production, intestinal permeability, and microbiome composition were similar between groups.

conclusionsPsyllium fiber reduced the number of abdominal pain episodes in children with IBS, independent of psychological factors. Psyllium did not alter breath hydrogen or methane production, gut permeability, or microbiome composition. ClinicalTrials.gov no: NCT00526903.

Indexed as

Abdominal PainAdolescentBreath TestsChildDietary FiberDouble-Blind MethodFemaleHumansIrritable Bowel SyndromeMalePlacebosPsylliumTreatment OutcomeDietary FiberPlacebosPsylliumAbdominal PainFiberIrritable Bowel SyndromeMicrobiomePsyllium

Identifiers

PMID27080737
PMCPMC5064811
OpenAlexW2329980267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.