ArticleJournal of neurotrauma2017
Long-Term Neuropsychological Profiles and Their Role as Mediators of Adaptive Functioning after Traumatic Brain Injury in Early Childhood.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed.
- Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.Journal of neurotrauma · 2021Trial
- Recovery Trajectories of Child and Family Outcomes Following Online Family Problem-Solving Therapy for Children and Adolescents after Traumatic Brain Injury.Journal of the International Neuropsychological Society : JINS · 2019Trial
- Evaluating cognitive performance using cognitive performance using the National Institutes of Health Toolbox Cognitive Battery in children with traumatic brain injury.Journal of the International Neuropsychological Society : JINS · 2025Article
- From brain injury to classroom: cognitive and academic outcomes after pediatric stroke. A narrative review.Frontiers in neurology · 2025Review
- Differences between parent- and teacher-reported executive functioning behaviors after traumatic injuries.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Exposure to Sedation and Analgesia Medications: Short-term Cognitive Outcomes in Pediatric Critical Care Survivors With Acquired Brain Injury.Journal of intensive care medicine · 2024Article
- Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery.Biomolecules · 2024Review
- Adaptive functioning and academic achievement in pediatric survivors of acute lymphoblastic leukemia: Associations with executive functioning, socioeconomic status, and academic support.European journal of haematology · 2024Article
- Traumatic brain injuries: a neuropsychological review.Frontiers in behavioral neuroscience · 2024Review
- Posttraumatic epilepsy in critically ill children with traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury.Journal of the International Neuropsychological Society : JINS · 2023Article
- Intelligence and executive function are associated with age at insult, time post-insult, and disability following chronic pediatric acquired brain injury.Frontiers in neurology · 2023Article
- Variability Across Caregiver and Performance-Based Measures of Executive Functioning in an Acute Pediatric Neurocritical Care Population.Neurotrauma reports · 2023Article
- Back to School: Academic Functioning and Educational Needs among Youth with Acquired Brain Injury.Children (Basel, Switzerland) · 2022Review
- Sleep and Executive Functioning in Pediatric Traumatic Brain Injury Survivors after Critical Care.Children (Basel, Switzerland) · 2022Article
- Surface-based abnormalities of the executive frontostriatial circuit in pediatric TBI.NeuroImage. Clinical · 2022Article
- Brain-Derived Neurotrophic Factor Val66Met and Behavioral Adjustment after Early Childhood Traumatic Brain Injury.Journal of neurotrauma · 2022Article
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- Long-Term Outcome of PICU Patients Discharged With New, Functional Status Morbidity.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The objectives of the study were to characterize long-term neuropsychological outcomes following traumatic brain injury (TBI) sustained during early childhood, and determine whether identified neuropsychological impairments mediated the effect of TBI on long-term adaptive functioning. Participants included 16 children with severe TBI, 42 children with moderate TBI, and 72 children with orthopedic injuries (OI) sustained between ages 3 and 7 years. Children completed neuropsychological tests and caregivers completed a structured interview of child adaptive functioning at 6.9 (±1.10) years post-injury. Profile analysis and multiple mediator modeling were employed. Children with severe TBI demonstrated poorer fluid reasoning and inhibitory control than both children with moderate TBI and OI, as well as slower processing speed than the OI group. Both fluid reasoning and processing speed were significant independent mediators of the effect of severe TBI on adaptive functioning. No neuropsychological measure significantly mediated the effect of moderate TBI on adaptive functioning. Children sustaining early severe TBI demonstrate persisting neuropsychological impairments into adolescence and young adulthood. The impact of severe TBI on children's long-term adaptive functioning is mediated in part by its effects on fluid reasoning and processing speed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.