ArticleMagnetic resonance in medicine2017
Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Mineral coated microparticles delivering Interleukin-4, Interleukin-10, and Interleukin-13 reduce inflammation and improve function after spinal cord injury in a rat.Experimental neurology · 2025Article
- Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.Neurotrauma reports · 2025Article
- Influence of preprocessing, distortion correction and cardiac triggering on the quality of diffusion MR images of spinal cord.Magnetic resonance imaging · 2024Article
- The Role of Magnetic Resonance Imaging and Computed Tomography in Spinal Cord Injury.Life (Basel, Switzerland) · 2023Review
- Both noise-floor and tissue compartment difference in diffusivity contribute to FA dependence on b-value in diffusion MRI.Human brain mapping · 2023Article
- Acute Magnetic Resonance Imaging Predictors of Chronic Motor Function and Tissue Sparing in Rat Cervical Spinal Cord Injury.Journal of neurotrauma · 2022Article
- Estimating axial diffusivity in the NODDI model.NeuroImage · 2022Article
- Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.NeuroImage · 2022Review
- Performance of orientation distribution function-fingerprinting with a biophysical multicompartment diffusion model.Magnetic resonance in medicine · 2022Article
- Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes.Addiction biology · 2022Article
- Filtered Diffusion-Weighted MRI of the Human Cervical Spinal Cord: Feasibility and Application to Traumatic Spinal Cord Injury.AJNR. American journal of neuroradiology · 2021Article
- Relationships between spinal cord blood flow measured with flow-sensitive alternating inversion recovery (FAIR) and neurobehavioral outcomes in rat spinal cord injury.Magnetic resonance imaging · 2021Article
- Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain.Brain : a journal of neurology · 2021Article
- Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in mouse brain.NMR in biomedicine · 2021Article
- The present and the future of microstructure MRI: From a paradigm shift to normal science.Journal of neuroscience methods · 2021Review
- Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging.NeuroImage · 2020Article
- Challenges for biophysical modeling of microstructure.Journal of neuroscience methods · 2020Review
- Diffusion MRI microstructural models in the cervical spinal cord - Application, normative values, and correlations with histological analysis.NeuroImage · 2019Article
- Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation.NMR in biomedicine · 2019Review
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation.PloS one · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDiffusion-weighted imaging is a common experimental tool for evaluating spinal cord injury (SCI), yet it suffers from complications that decrease its clinical effectiveness. The most commonly used technique, diffusion tensor imaging (DTI), is often confounded by effects of edema accompanying acute SCI, limiting its sensitivity to the important functional status marker of axonal integrity. The purpose of this study is to introduce a novel diffusion-acquisition method with the goal of overcoming these limitations.
methodsA double diffusion encoding (DDE) pulse sequence was implemented with a diffusion-weighted filter orthogonal to the spinal cord for suppressing nonneural signals prior to diffusion weighting parallel to the cord. A point-resolved spectroscopy readout (DDE-PRESS) was used for improved sensitivity and compared with DTI in a rat model of SCI with varying injury severities.
resultsThe DDE-PRESS parameter, restricted fraction, showed a strong relationship with injury severity (P < 0.001, R
conclusionsIn a rat model of SCI, DDE-PRESS demonstrated high sensitivity to injury with substantial decreases in acquisition time and data processing. This method shows promise for application in rapid evaluation of SCI severity. Magn Reson Med 77:1639-1649, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.