ArticleAdvances in experimental medicine and biology2016
Speech Coding in the Midbrain: Effects of Sensorineural Hearing Loss.
Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neural Fluctuation Contrast as a Code for Complex Sounds: The Role and Control of Peripheral Nonlinearities.Hearing research · 2024Review
- Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention.Current topics in medicinal chemistry · 2024Review
- Effects of sensorineural hearing loss on formant-frequency discrimination: Measurements and models.Hearing research · 2023Article
- Distorted Tonotopy Severely Degrades Neural Representations of Connected Speech in Noise following Acoustic Trauma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Animal-to-Human Translation Difficulties and Problems With Proposed Coding-in-Noise Deficits in Noise-Induced Synaptopathy and Hidden Hearing Loss.Frontiers in neuroscience · 2022Review
- Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing.Frontiers in neuroscience · 2022Article
- Amplitude modulation transfer functions reveal opposing populations within both the inferior colliculus and medial geniculate body.Journal of neurophysiology · 2020Article
- Neural fluctuation cues for simultaneous notched-noise masking and profile-analysis tasks: Insights from model midbrain responses.The Journal of the Acoustical Society of America · 2020Article
- Nonlinear auditory models yield new insights into representations of vowels.Attention, perception & psychophysics · 2019Article
- Supra-Threshold Hearing and Fluctuation Profiles: Implications for Sensorineural and Hidden Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2018Review
- Identified GABAergic and Glutamatergic Neurons in the Mouse Inferior Colliculus Share Similar Response Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sensorineural Hearing Loss Diminishes Use of Temporal Envelope Cues: Evidence From Roving-Level Tone-in-Noise Detection.Ear and hearingArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In response to voiced speech sounds, auditory-nerve (AN) fibres phase-lock to harmonics near best frequency (BF) and to the fundamental frequency (F0) of voiced sounds. Due to nonlinearities in the healthy ear, phase-locking in each frequency channel is dominated either by a single harmonic, for channels tuned near formants, or by F0, for channels between formants. The alternating dominance of these factors sets up a robust pattern of F0-synchronized rate across best frequency (BF). This profile of a temporally coded measure is transformed into a mean rate profile in the midbrain (inferior colliculus, IC), where neurons are sensitive to low-frequency fluctuations. In the impaired ear, the F0-synchronized rate profile is affected by several factors: Reduced synchrony capture decreases the dominance of a single harmonic near BF on the response. Elevated thresholds also reduce the effect of rate saturation, resulting in increased F0-synchrony. Wider peripheral tuning results in a wider-band envelope with reduced F0 amplitude. In general, sensorineural hearing loss reduces the contrast in AN F0-synchronized rates across BF. Computational models for AN and IC neurons illustrate how hearing loss would affect the F0-synchronized rate profiles set up in response to voiced speech sounds.
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Registered trials
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