Evidence map›Paper›PMID 27080566›Full record

ArticleMagnetic resonance in medicine2017

The Effect of Microcirculatory Flow on Oscillating Gradient Diffusion MRI and Diffusion Encoding with Dual-Frequency Orthogonal Gradients (DEFOG).

Dan Wu, Jiangyang Zhang

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Nonparametric 5D D-RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  6. Review
  7. Feasibility of oscillating and pulsed gradient diffusion MRI to assess neonatal hypoxia-ischemia on clinical systems.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Oscillating-gradient diffusion magnetic resonance imaging detects acute subcellular structural changes in the mouse forebrain after neonatal hypoxia-ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dan WuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiangyang ZhangDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
Mapping gene expression in the developing mouse brainR01NS070909 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHANG, JIANGYANG · 2010 to 2014
$1.7M
In-utero characterization of embryonic mouse brain development and injury with MRIR21NS098018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, DAN · 2016 to 2017
$461k
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD074593NINDS NIH HHS R01 NS070909NINDS NIH HHS R21 NS098018
6 · The paper itself

Abstract

purposeWe investigated the effect of microcirculatory flow on oscillating gradient spin echo (OGSE) diffusion MRI at low b-values and developed a diffusion preparation method called diffusion encoding with dual-frequency orthogonal gradients (DEFOG) to suppress the effect.

methodsCompared to conventional OGSE sequences, DEFOG adds a pulsed gradient that is orthogonal to the oscillating gradient and has a moderate diffusion weighting (e.g., 300 s/mm

resultsApparent diffusion coefficients (ADCs) measured using a conventional OGSE sequence at low b-values (< 200 mm

conclusionMicrocirculatory flow affects OGSE diffusion MRI measurements at low b-values, and this effect can be suppressed using the DEFOG method. Magn Reson Med 77:1583-1592, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

ArtifactsSignal Processing, Computer-AssistedAlgorithmsAnimalsBlood Flow VelocityDiffusion Magnetic Resonance ImagingImage EnhancementImage Interpretation, Computer-AssistedMaleMiceMice, Inbred C57BLMicrocirculationOscillometryReproducibility of ResultsSensitivity and Specificitydiffusion MRIdual-frequency orthogonal gradientsmicrocirculatory flowmouse brainoscillating gradientpseudo-diffusion

Identifiers

PMID27080566
PMCPMC5568088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.